Sick sinus syndrome associated with topical timolol maleate instillation

Harpreet S. Walia; Sandeep S. Walia; Matthew E. Emanuel

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Sick sinus syndrome associated with topical timolol maleate instillation

机译：病态窦房结综合征伴马来酸替莫洛尔滴注

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A 70-year-old black woman presented with intermittent palpitations and dyspnea was found to be bradycardic with a normal sinus rhythm. She had instilled her topical timolol maleate approximately 30 minutes prior to each of these episodes. Topical timolol was discontinued and the conduction abnormality resolved. She was diagnosed as having intermittent sinus bradycardia with intermittent atrioventricular block, likely induced by topical beta-blocker therapy. Topical timolol maleate is an effective treatment for ocular hypertension, acting by reducing aqueous fluid production. However, it can induce systemic side effects and should be used with caution in patients with, or predisposed to, cardiac or respiratory depression.Keywords: Beta blocker, sick sinus syndrome, timolol

机译：一名70岁的黑人妇女出现间歇性心pal和呼吸困难，发现其心动过缓且窦性心律正常。在这些发作中的每一次发作之前约30分钟，她都已滴注了局部使用的马来酸替莫洛尔。停止局部使用替莫洛尔，并消除传导异常。她被诊断为间歇性窦性心动过缓，间歇性房室传导阻滞，可能是由局部β受体阻滞剂治疗引起的。马来酸替莫洛尔局部用药是一种有效的治疗高眼压的药物，其作用是减少水液的产生。然而，它会诱发全身性副作用，在患有或易患心脏或呼吸抑制的患者中应谨慎使用。关键字：β受体阻滞剂，病态窦房结综合征，噻吗洛尔

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《Journal of Pharmacology and Pharmacotherapeutics》 |2011年第4期|共3页
作者
Harpreet S. Walia; Sandeep S. Walia; Matthew E. Emanuel;
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中图分类药理学;
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1. Comparison of the efficacy on intraocular pressure and retinal blood flow of a beta-blocker (timolol maleate) against the fixed association of a topical carbonic anhydrase (dorzolamide) and a beta-blocker (timolol maleate). [J] . Brogliatti B, Rolle T, Vizzeri GM, Acta ophthalmologica Scandinavica . 2000,第232期

机译：比较β受体阻滞剂（马来酸替莫洛尔）对局部碳酸酐酶（多佐胺）和β受体阻滞剂（马来酸替莫洛尔）的固定结合对眼内压和视网膜血流的功效。
2. The value of adenosine test in the diagnosis of sick sinus syndrome: susceptibility of sinus and atrioventricular node to adenosine in patients with sick sinus syndrome and unexplained syncope [J] . Nikolaos Fragakis, Ilias Iliadis, Emmanouil Sidopoulos, Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2007,第8期

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3. The value of adenosine test in the diagnosis of sick sinus syndrome: susceptibility of sinus and atrioventricular node to adenosine in patients with sick sinus syndrome and unexplained syncope [J] . Nikolaos Fragakis1 Ilias Iliadis2 Emmanouil Sidopoulos2 Alexandra Lambrou2 Evangelos Tsaritsaniotis2 and George Katsaris2 Europace . 2007,第8期

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4. PHENOTYPICAL OVERLAPPING OF SICK SINUS ANDBRUGADA SYNDROMES IN A FAMILY WITH A NOVELSCN5A MUTATION [C] . FUMIKO YANAGISAWA, YUKEIHIGASHI, HIS A SHIMOJIM International Congress on Electrocardiology . 2005

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5. Assessment by autonomic blockade of age-related changes of the sinus node function and autonomic regulation in sick sinus syndrome [D] . Kuga Keisuke 1988

机译：通过自主神经阻滞评估与年龄相关的病态窦房结的窦房结功能变化和自主神经调节
6. Topical Application of 0.5 Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma [O] . Hai Wei Wu, Chao Liu, Xuan Wang, 2017

机译：0.5％马来酸替莫洛尔水凝胶局部治疗小儿浅表血管瘤的局部应用
7. Sick sinus syndrome associated with topical timolol maleate instillation [O] . Walia, Harpreet S., Walia, Sandeep S., Emanuel, Matthew E. 2011

机译：病态窦房结综合征伴马来酸替莫洛尔滴注

Sick sinus syndrome associated with topical timolol maleate instillation

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