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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Appropriateness of Ticagrelor Use at Initiation: A Population-Based Cohort Study
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Appropriateness of Ticagrelor Use at Initiation: A Population-Based Cohort Study

机译：在开始使用替卡格雷时的适当性：一项基于人群的队列研究

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Abstract Purpose . Ticagrelor is recommended following an acute coronary syndrome if used appropriately. Its use has not yet been well described in the context of ambulatory clinical practice. The objective of this study was to assess the proportion of ticagrelor new users who initiated this medication appropriately and explore associated factors. Methods . A retrospective population-based inception cohort study was conducted using Quebec administrative databases. The study population included all Quebec residents aged ≥18 years who had a first ticagrelor prescription claim between 1 January, 2012, and 31 March, 2015, and had been continuously eligible in the Quebec public drug plan during the 365 days preceding the first ticagrelor claim. The initial ticagrelor prescription was considered appropriate if:1) it met the indication for use criterion, 2) the prescribed daily dose was 90 mg twice a day, and 3) there was a concomitant use of acetylsalicylic acid (ASA) 80–81 mg daily. Factors potentially associated with the ticagrelor appropriateness of use were included in a logistic log-binomial regression model. Results . A total of 7,073 patients were included in the study, 6,013 (85.0%) had an appropriate indication, 6,895 (97.5%) were prescribed ticagrelor 90 mg twice a day, and 6,385 (90.3%) had a concomitant prescription of ASA. A total of 5,371 (75.9%) patients were prescribed ticagrelor in accordance with all criteria. Twelve factors were associated with prescription appropriateness. Conclusions . A large majority of patients initiated ticagrelor appropriately. Further improvement in appropriateness may come at targeting indication for use.
机译：抽象目的。如果使用得当，建议在急性冠状动脉综合征后使用替卡格雷。在门诊临床实践中，尚未很好地描述其用途。这项研究的目的是评估适当使用该药物的替卡格雷新使用者的比例，并探讨相关因素。方法 。使用魁北克省行政数据库进行了一项基于人群的回顾性队列研究。研究人群包括所有年龄≥18岁的魁北克居民，他们在2012年1月1日至2015年3月31日期间首次提出替卡格雷的处方要求，并且在第一次替卡格雷的要求之前的365天一直符合魁北克公共药物计划的要求。如果满足以下条件，则认为替卡格雷的初始处方是合适的：1）符合使用指示，2）每日两次的处方日剂量为90 mg，3）同时使用乙酰水杨酸（ASA）80–81 mg日常。逻辑对数二项式回归模型中包括与替卡瑞洛使用的适当性潜在相关的因素。结果。共有7,073名患者被纳入研究，其中6,013名（85.0％）有适当的适应症，6,895名（97.5％）接受替卡格雷或每天两次90 mg的处方，并且6,385名（90.3％）伴有ASA处方。根据所有标准，总共为5,371名（75.9％）患者开了替卡格雷的处方药。十二个因素与处方的适当性有关。结论。绝大多数患者适当地开始替卡格雷治疗。适当性的进一步改善可能会针对使用指示。

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