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首页> 外文期刊>Journal of Pharmacopuncture >Toxicity of Single-dose Intramuscular Injection of Samjeong Pharmacopuncture in Sprague-Dawley Rats
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Toxicity of Single-dose Intramuscular Injection of Samjeong Pharmacopuncture in Sprague-Dawley Rats

机译：肌注单剂量肌肉注射对Sprague-Dawley大鼠的毒性

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Objectives: This study was carried out in order to find both the single-dose intramuscular injection toxicity and the approximate lethal dose of samjeong pharmacopuncture (SP) in Sprague-Dawley (SD) rats. Methods: The SD rats in this study were divided into four groups, one control group (1.0 mL/animal, normal saline) and three experimental groups (0.25, 0.5, and 1.0 mL/animal, SP). All groups consisted of five male and five female rats. SP was injected as a single-dose intramuscularly at the thigh. After the injection, general symptoms and weight were observed for 14 days. After the observations had ended, hematologic and serum biochemical examinations, necropsy and a local tolerance test at the injection site were performed. The experiments were carried out at the Good Laboratory Practice firm, Biotoxtech Co. (Cheongwon, Chungbuk). Animal experiments were approved by the Ethics Committee (Approval Number: 130379). Results: No deaths occurred in any of the three experimental groups. The injection of SP had no effects on the general symptoms, body weights, results of the hematologic, and serum biochemical examinations, and necropsy findings. In local tolerance tests at the injection sites, mild inflammation was observed in the experimental group, but it did not appear to be a treatment related effect. Conclusion: Under the conditions of this test, the results from the injection of SP suggest that the approximate lethal dose of SP is above 1.0 mL/animal for both male and female SD rats. Therefore, the clinical use of SP is thought to be safe.
机译：目的：进行这项研究的目的是为了发现Sprague-Dawley（SD）大鼠的单剂量肌内注射毒性和samjeong药物针刺（SP）的近似致死剂量。方法：本研究将SD大鼠分为四组，一个对照组（1.0 mL /动物，生理盐水）和三个实验组（0.25、0.5和1.0 mL /动物，SP）。所有组由五只雄性和五只雌性大鼠组成。在大腿肌肉注射SP单剂。注射后14天，观察到一般症状和体重。观察结束后，在注射部位进行血液学和血清生化检查，尸检和局部耐受性测试。实验是在良好实验室规范公司Biotoxtech Co.（忠清北道清原市）进行的。动物实验获得伦理委员会的批准（批准号：130379）。结果：三个实验组均未发生死亡。注射SP对一般症状，体重，血液学和血清生化检查结果以及尸检结果没有影响。在注射部位的局部耐受性测试中，在实验组中观察到轻度的炎症，但似乎与治疗无关。结论：在该试验条件下，SP的注射结果表明，雄性和雌性SD大鼠的近似SP致死剂量均大于1.0 mL /动物。因此，SP的临床使用被认为是安全的。

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