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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Safranal Treatment Improves Hyperglycemia, Hyperlipidemia and Oxidative Stress in Streptozotocin-Induced Diabetic Rats
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Safranal Treatment Improves Hyperglycemia, Hyperlipidemia and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

机译：fra胺治疗可改善链脲佐菌素诱发的糖尿病大鼠的高血糖，高血脂和氧化应激

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Purpose. Clinical research has confirmed the efficacy of several plant extracts in the modulation of oxidative stress associated with diabetes mellitus. Findings indicate that safranal has antioxidant properties. The aim of the present study was the evaluation of possible protective effects of safranal against oxidative damage in diabetic rats. Methods. In this study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three safranal (0.25, 0.50, 0.75 mg/kg/day)-treated diabetic groups. Diabetes was induced by streptozotocin (STZ) in rats. STZ was injected intraperitoneally at a single dose of 60 mg/kg for diabetes induction. Safranal (intraperitoneal injection) was administered 3 days after STZ administration; these injections were continued to the end of the study (4 weeks). At the end of the 4-week period, blood was drawn for biochemical assays. In order to determine the changes of cellular antioxidant defense systems, antioxidant enzymes including glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were measured in serum. Moreover we also measured serum nitric oxide (NO) and serum malondialdehyde (MDA) levels, a marker of lipid peroxidation. Results. STZ-induced diabetes caused an elevation ( p < 0.001) of blood glucose, MDA, NO, total lipids, triglycerides and cholesterol, with reduction of GSH level and CAT and SOD activities. The results indicated that the significant elevation in the blood glucose, MDA, NO, total lipids, triglycerides, cholesterol and reduction of glutathione level and CAT and SOD activity were ameliorated in the safranal–treated diabetic groups compared with the untreated groups, in a dose dependent manner ( p < 0.05, p <0.01, p < 0.001). Conclusion. These results suggest that safranal has antioxidant properties and improves chemically-induced diabetes and its complications by modulation of oxidative stress . This article is open to POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking on on the issue’s contents page.
机译：目的。临床研究证实了几种植物提取物在调节与糖尿病有关的氧化应激中的功效。研究结果表明，sa草具有抗氧化特性。本研究的目的是评估of胺对糖尿病大鼠可能的氧化损伤的保护作用。方法。在这项研究中，将大鼠分为以下每组8只动物的组：对照组，未经治疗的糖尿病组，三只经腹部（0.25、0.50、0.75 mg / kg / day）治疗的糖尿病组。链脲佐菌素（STZ）在大鼠中诱发糖尿病。腹腔注射STZ剂量为60 mg / kg，用于诱导糖尿病。 STZ给药后3天进行腹腔注射（腹膜内注射）。这些注射一直持续到研究结束（4周）。在4周时间结束时，抽取血液进行生化分析。为了确定细胞抗氧化防御系统的变化，在血清中测量了包括谷胱甘肽过氧化物酶（GSHPx），超氧化物歧化酶（SOD）和过氧化氢酶（CAT）等抗氧化酶的活性。此外，我们还测量了血清一氧化氮（NO）和血清丙二醛（MDA）的水平，脂质过氧化的标志物。结果。 STZ诱导的糖尿病导致血糖，MDA，NO，总脂质，甘油三酸酯和胆固醇升高（p <0.001），同时降低GSH水平以及CAT和SOD活性。结果表明，与未经治疗的糖尿病组相比，经剂量处理的糖尿病组糖尿病患者的血糖，MDA，NO，总脂质，甘油三酯，胆固醇和谷胱甘肽水平以及CAT和SOD活性的显着升高均得到改善。依赖方式（p <0.05，p <0.01，p <0.001）。结论。这些结果表明，safranal具有抗氧化特性，并通过调节氧化应激改善了化学诱导的糖尿病及其并发症。本文对POST-PUBLICATION REVIEW开放。已注册的读者（请参阅“针对读者”）可以通过单击问题的内容页面来发表评论。

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