• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Receptor, Ligand and Channel Research >The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases
【24h】

The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases

机译：sigma-1受体在神经精神疾病的病理生理中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: The endoplasmic reticulum protein sigma-1 receptors, first regarded as opioid receptors and later confused as the phencyclidine (PCP) binding sites of the N-methyl-D-aspartate (NMDA) receptor, are now confirmed to be independent receptors. They are involved in the modulation of various neurotransmitter systems and have a high affinity for diverse classes of psychotropic drugs. Accumulating evidence suggests that the sigma-1 receptors are implicated in higher-ordered brain functions and play important roles in the pathophysiology of neuropsychiatric diseases such as schizophrenia, depression, anxiety disorders, and dementia. Recently, sigma-1 receptors have been shown to function at the molecular level as “receptor chaperones.” This mechanism may unify the explanation of the role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases. With the development of the positron emission tomography (PET) ligand [11C]SA4503, it has become possible to visualize sigma-1 receptors and estimate the sigma-1 receptor occupancy of drugs in the human brain. This approach may provide additional information on the function of sigma-1 receptors. This article reviews the function of sigma-1 receptors and attempts to reinterpret their role in the pathophysiology of neuropsychiatric diseases based on their new description as “receptor chaperones.”
机译：摘要：内质网蛋白sigma-1受体首先被认为是阿片样物质受体，后来又被混淆为N-甲基-D-天冬氨酸（NMDA）受体的苯环利定（PCP）结合位点，现已被证实是独立的受体。它们参与各种神经递质系统的调节，并且对多种精神药物具有高度亲和力。越来越多的证据表明，sigma-1受体与高级脑功能有关，并且在神经精神疾病如精神分裂症，抑郁症，焦虑症和痴呆症的病理生理中起重要作用。最近，已证明sigma-1受体在分子水平上起“受体伴侣”的作用。这种机制可能统一解释sigma-1受体在神经精神疾病的病理生理中的作用。随着正电子发射断层扫描（PET）配体[11C] SA4503的发展，可以可视化sigma-1受体并估计人脑中药物的sigma-1受体占有率。这种方法可能会提供有关sigma-1受体功能的其他信息。本文回顾了sigma-1受体的功能，并尝试根据新的描述为“受体伴侣”来重新解释其在神经精神疾病的病理生理中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号