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首页> 外文期刊>Journal of Receptor, Ligand and Channel Research >The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects
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The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects

机译：人达菲抗原受体对趋化因子在疟疾易感性中的作用：当前观点和未来治疗前景

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摘要

The Duffy antigen receptor for chemokine (DARC) is a nonspecific receptor for several proinflammatory cytokines. It is homologous to the G-protein chemokine receptor superfamily, which is suggested to function as a scavenger in many inflammatory-and proinflammatory-related diseases. G-protein chemokine receptors are also known to play a critical role in infectious diseases; they are commonly used as entry vehicles by infectious agents. A typical example is the chemokine receptor CCR5 or CXCR4 used by HIV for infecting target cells. In malaria, DARC is considered an essential receptor that mediates the entry of the human and zoonotic malaria parasites Plasmodium vivax and Plasmodium knowlesi into human reticulocytes and erythrocytes, respectively. This process is mediated through interaction with the parasite ligand known as the Duffy binding protein (DBP). Most therapeutic strategies have been focused on blocking the interaction between DBP and DARC by targeting the parasite ligand, while strategies targeting the receptor, DARC, have not been intensively investigated. The rapid increase in drug resistance and the lack of new effective drugs or a vaccine for malaria constitute a major threat and a need for novel therapeutics to combat disease. This review explores strategies that can be used to target the receptor. Inhibitors of DARC, which block DBP–DARC interaction, can potentially provide an effective strategy for preventing malaria caused by P. vivax .
机译：Duffy趋化因子抗原受体（DARC）是几种促炎性细胞因子的非特异性受体。它与G蛋白趋化因子受体超家族同源，被认为在许多炎症和促炎相关疾病中起清除剂的作用。还已知G蛋白趋化因子受体在传染病中起关键作用。它们通常被传染媒介用作进入媒介。一个典型的例子是HIV用于感染靶细胞的趋化因子受体CCR5或CXCR4。在疟疾中，DARC被认为是介导人类和人畜共患疟原虫间日疟原虫和诺氏疟原虫进入人网状细胞和红细胞的必不可少的受体。该过程是通过与称为Duffy结合蛋白（DBP）的寄生虫配体相互作用而介导的。大多数治疗策略都集中在通过靶向寄生虫配体来阻断DBP和DARC之间的相互作用，而针对受体DARC的策略尚未得到深入研究。耐药性的迅速增加以及缺乏用于疟疾的新的有效药物或疫苗构成了主要的威胁，并且需要对抗疾病的新型疗法。这篇综述探讨了可用于靶向受体的策略。阻止DBP-DARC相互作用的DARC抑制剂可以潜在地提供预防由间日疟原虫引起的疟疾的有效策略。

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