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首页> 外文期刊>Journal of Research in Dental Sciences >Clinical effects of chlorhexidine gel in the treatment of chronic periodontitis
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Clinical effects of chlorhexidine gel in the treatment of chronic periodontitis

机译：氯己定凝胶治疗慢性牙周炎的临床效果

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Background and Aim Local antibacterial agents containing chlorhexidine (CHX) are used as an adjunct to conventional treatment in periodontal patients. In this study, a sustained release, xanthan- based CHX gel was used for non surgical treatment in moderate to advanced periodontitis.Methods and Materials In this randomized controlled split-mouth clinical trial, 40 periodontal pockets with probing pocket depth 5 mm were selected and randomly assigned to the case and control groups. Scaling and root planing (SRP) were performed thoroughly at all sites. Then, chlorhexidine gel and placebo gel were applied subgingivally in test and control sites, respectively. The gels’ application was done two times with one week interval. The clinical parameters including plaque index (PI), papillary bleeding index (PBI), pocket depth (PD) and clinical attachment level (CAL) were evaluated at baseline, after 1 and 3 months. Data analysis was performed using U Mann-Whitney and Friedman tests.Results Statistically significant improvements were observed in PBI, CAL and PD parameters following treatment in each group after 1 and 3 months. Comparison between the two treatment groups showed no significant differences in clinical parameters at any time point.Conclusion According to the findings of this study, adjunctive subgingival application of chlorhexidine gel did not improve clinical parameters significantly compared to scaling and root planing treatment in moderate-to-severe chronic periodontitis.Key words Locally delivered drugs, Chronic periodontitis, Chlorhexidine,Treatment Outcome.
机译：背景与目的含有洗必泰（CHX）的局部抗菌剂被用作牙周患者常规治疗的辅助手段。在这项研究中，以黄原胶为基础的缓释CHX凝胶用于中度至晚期牙周炎的非手术治疗。方法和材料在这项随机对照的双口临床试验中，选择40个牙周袋，探查袋深度> 5 mm。并随机分配给病例组和对照组。在所有站点都彻底执行了缩放和根计划（SRP）。然后，将氯己定凝胶和安慰剂凝胶分别在测试部位和对照部位龈下施用。凝胶的涂装两次进行，间隔为一周。在基线后1个月和3个月后评估临床参数，包括斑块指数（PI），乳头出血指数（PBI），囊袋深度（PD）和临床附着水平（CAL）。使用U Mann-Whitney和Friedman检验进行数据分析。结果在治疗1个月和3个月后，各组的PBI，CAL和PD参数均有统计学上的显着改善。两个治疗组之间的比较在任何时间点都没有临床参数的显着差异。结论根据本研究的结果，在中度至中度洗牙和根部平整治疗中，洗必泰辅助龈下应用对临床参数没有明显改善。 -重度慢性牙周炎。关键词局部给药药物，慢性牙周炎，洗必泰，治疗结果。

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