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首页> 外文期刊>Journal of pesticide science >Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea
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Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea

机译：具有马来酸酐或二甲基马来酰亚胺结构的简单化合物对灰葡萄孢的抗真菌活性

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摘要

Compounds with maleic anhydride or maleimide presented considerable antifungal activity, and several maleimide derivatives have been reported to possess marginal or null zootoxic activity. In order to research the antifungal activity of the maleic anhydride or maleimide structure in these compounds, 44 related compounds were purchased or synthesized, and their MICs against Botrytis cinerea were investigated. The results showed that most maleic anhydrides and maleimides presented antifungal activity against B. cinerea . 2,3-Dimethyl maleic anhydride had the highest activity (MIC=3?μg/mL) among the 27 simple compounds with maleic anhydride. Meanwhile, N -3,5-dichloroaniline-3,4-dimethylmaleimide was the best (MIC=0.1?μg/mL) of the 17 maleimide derivatives, with activities nearly equal to those of dichloran. Furthermore, the data in this article reveals that the polarity and steric hindrance of maleic anhydride derivatives could affect their antifungal activities.
机译：具有顺丁烯二酸酐或顺丁烯二酰亚胺的化合物表现出相当大的抗真菌活性，据报道，几种顺丁烯二酰亚胺衍生物具有微弱或无效的动物毒性。为了研究这些化合物中马来酸酐或马来酰亚胺结构的抗真菌活性，购买或合成了44种相关化合物，并研究了它们对灰葡萄孢的MIC。结果表明，大多数马来酸酐和马来酰亚胺表现出对灰葡萄孢的抗真菌活性。 2,3-二甲基马来酸酐的活性最高（MIC = 3？μg/ mL）在27种具有马来酸酐的简单化合物中。同时，N -3,5-二氯苯胺-3,4-二甲基马来酰亚胺是最佳的（MIC = 0.1？μg/ mL），在17种马来酰亚胺衍生物中，其活性几乎与二氯甲烷相等。此外，本文中的数据表明，马来酸酐衍生物的极性和位阻可能会影响其抗真菌活性。

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