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Is the transition from chemistry to biology a mystery?

机译:从化学到生物学的转变是一个谜吗?

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Today most chemists think that the answer to how life on earth emerged is still unknown. They assume a gap between chemistry and biology that is still unbridged. For chemists, understanding the origin of life requires the experimental modeling of a process that bridges this gap. They will not consider the problem solved before they are able to perform such tasks. No gap appears when we are pursuing a less ambitious goal, namely, to present a sequence of hypothetical processes that lead to an apparatus with the basic structure and fundamental feature of the genetic apparatus of biosystems but strongly simplified. The modeled apparatus has the basic machinery of living entities. Its fundamental feature is Darwinian behavior. Living individuals have the power to evolve toward ever increasing complexity and intricacy if appropriate conditions are given. The task to understand life's origin as a rational process is closely related to the earlier attempts of the present author to design and construct supra-molecular machines. The skill of the experimentalist has to be replaced by the presence of very particular conditions given by chance in a very particular location. The resulting apparatus has a distinct basic structure and function. The essence of what happens is inevitable, not accidental. Thus the emergence of life is assumed to be described by a distinct theory. Today's great challenge is experimentally investigating chemical systems with the goal of creating artificial chemical life and the given theory provides a powerful stimulus. Life, from the perspective of physics, is the living state of matter and this view calls for a theory describing the fundamental requirements for the appearance of such a living state of matter (on the early earth and in the universe). The approach given here is an attempt in this direction. According to that approach the appearance of an entity with Darwinian behavior is instantaneous and linked with the creation of matter that carries information. Thus, Information (measured in bits according to Shannon) takes a meaning with that instant, the appearance of the first entity that evolves by multiplication, variation, selection and keeps that meaning during the entire evolution of the living (Information carrying) state of matter. Another consequence of this initial event is a spontaneous symmetry breaking due to the equal probabilities that the oligomer starting the process is right handed or left handed.
机译:今天,大多数化学家认为,关于地球生命如何出现的答案仍然未知。他们假设化学和生物学之间的鸿沟仍未消除。对于化学家来说,了解生命的起源需要对弥合这一差距的过程进行实验建模。在他们能够执行此类任务之前,他们不会考虑解决的问题。当我们追求一个不太雄心勃勃的目标时,即提出一系列假想过程,这些假想过程导致一种具有生物系统遗传设备的基本结构和基本特征的设备,但是却被大大简化,这没有任何差距。建模的设备具有生物实体的基本机制。它的基本特征是达尔文行为。如果有适当的条件,生活中的个体有能力朝日益复杂和复杂的方向发展。将生命起源理解为一个理性过程的任务与本作者早期设计和构建超分子机器的尝试紧密相关。必须由在非常特定的位置偶然提供的非常特殊的条件代替实验师的技能。所得装置具有独特的基本结构和功能。发生的本质是不可避免的,不是偶然的。因此,生命的出现被认为是由不同的理论来描述的。当今的巨大挑战是通过实验研究化学系统,以创造人造化学寿命,而给定的理论则提供了强有力的刺激。从物理学的角度来看,生命是物质的生命状态,这种观点要求一种理论来描述这种物质的生命状态(在早期地球和宇宙中)的基本要求。这里给出的方法是朝这个方向的尝试。根据这种方法,具有达尔文行为的实体的出现是瞬时的,并且与携带信息的物质的产生有关。因此,信息(根据香农(Shannon)以比特为单位)具有该瞬间的意义,即通过乘法,变异,选择而演化的第一个实体的出现,并在物质的整个生命(信息携带)状态的整个演化过程中保持该意义。 。该初始事件的另一个结果是,由于启动过程的低聚物是右手用左手或左手用左手的概率相同,因此自发对称性破裂。

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