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首页> 外文期刊>Journal of the Chinese Medical Association: JCMA >H1N1 influenza: Is traditional Chinese medicine effective and safe?
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H1N1 influenza: Is traditional Chinese medicine effective and safe?

机译：H1N1流感：中药有效吗？

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摘要

Influenza is a viral respiratory infection that causes an acute febrile illness with myalgia, headache, and cough, and can result in substantially elevated morbidity and mortality rates during an epidemic.1 A novel influenza H1N1 infection began in March 2009, which rapidly spread and caused the World Health Organization to declare the first influenza pandemic outbreak.2 The antiviral medication oseltamivir has been approved for use against influenza H1N1 infections; however, careful use of anti-influenza drugs has been recommended due to the emergence of drug resistance and the side effects of these drugs.3 Chinese herbal medicine, the most important component of traditional Chinese medicine (TCM), has been recommended for preventing and treating influenza due to the limitations of healthcare resources in China. Shang-Han Lun (Treatise of Exogenous Febrile Diseases or Discourse on Cold-Damage Disorders) and Wen-Bing-Tiao-Bian (Detailed Analysis of Epidemic Warm Diseases) were regarded as the seminal guidelines for treatment of influenza in TCM.4 In the study of TCM, influenza is differentiated into two types: (1) wind-cold syndrome and (2) wind-heat syndrome. Severe cold, slight fever, absence of sweat, headache, aching pain of the extremities, stuffy nose with nasal discharge, and cough with thin sputum are the primary symptoms of the wind-cold type. Alternatively, a high fever, slight aversion to cold, headache, sore throat with congestion, and expectoration of yellowish sputum are the main symptoms of the wind-heat type.5 Many studies have shown that Chinese herbal medicine applied to counter the effects of wind-cold or wind-heat types can inhibit influenza virus, with some studies even showing potential modulation of the cellular immune system in animals. For example, Scutellaria baicalensis inhibits influenza HIN1 by exerting cytotoxic activity against infected cells.6Hypericum perforatum L. could reduce the influenza HIN1 viral titer of infected mice by modulation of inflammatory cytokines.7 However, evidence-based data regarding the therapeutic effects and safety of TCM for treatment of influenza H1N1 in humans remain unclear.
机译：流感是一种病毒性呼吸道感染，会导致急性发热性疾病，伴有肌痛，头痛和咳嗽，并可能在流行期间导致发病率和死亡率大大提高。1一种新型的H1N1流感感染始于2009年3月，迅速蔓延并引起世界卫生组织宣布首例流感大流行爆发。2抗病毒药物奥司他韦已被批准用于治疗H1N1流感病毒;但是，由于耐药性的出现和这些药物的副作用，建议谨慎使用抗流感药。3建议使用中草药作为中药（TCM）的最重要组成部分，以预防和预防感染。由于中国医疗资源的限制，因此需要治疗流感。伦上汉（外来性温热疾病的治疗或关于冷害性疾病的论述）和文冰条变（流行性温热疾病的详细分析）被视为治疗中医流感的开创性指南。4在中医研究中，流感可分为两种类型：（1）风冷综合症和（2）风热综合症。严重的感冒，轻微发烧，没有汗水，头痛，四肢酸痛，鼻塞鼻涕，痰稀咳嗽是风冷型的主要症状。另外，高烧，轻度反感，头痛，咽喉充血，痰液发黄是风热型的主要症状。5许多研究表明，中草药可用于对抗风的影响。冷或风热类型可以抑制流感病毒，一些研究甚至显示了动物细胞免疫系统的潜在调节作用。例如，黄S通过对被感染的细胞发挥细胞毒活性来抑制HIN1流感病毒.6贯叶连翘可以通过调节炎症细胞因子来降低被感染小鼠的HIN1流感病毒滴度.7然而，关于黄of的治疗效果和安全性的循证数据目前尚不清楚中医用于治疗人类H1N1流感的方法。

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