...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Brazilian Chemical Society >Clusiaxanthone and tocotrienol Series from Clusia pernambucensis and their antileishmanial activity
【24h】

Clusiaxanthone and tocotrienol Series from Clusia pernambucensis and their antileishmanial activity

机译：南美楠clusiaxanthone和生育三烯酚系列及其抗疟活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Phytochemical analysis of the ethyl acetate extract from the stem bark of Clusia pernambucensis G. Mariz, Clusiaceae, a Brazilian Cerrado species, led to the isolation and full characterization of a new xanthone, 1,7-dihydroxy-2-(3-methyl-2-butenyl)-6',6'-dimethylpyrano(2',3':3,4)xanthone, namely clusiaxanthone. Four previously unreported tocotrienols from this species were also isolated. A derivative was obtained from clusiaxanthone, 1-hydroxy,7-methoxy-2-(3-methyl2-butenyl)-6',6'-dimethylpyrano(2',3':3,4)xanthone (7-O-methylclusiaxanthone), and an additional derivative was obtained from Z- δ -tocotrienoloic acid. The structures of these compounds were established based on data from 1H and 13C nuclear magnetic resonance (1D and 2D NMR), high resolution electrospray ionization mass spectrometry (HRESIMS) and infrared spectroscopy. The clusiaxanthone and its derivative were able to control macrophage infection by Leishmania (Leishmania) amazonensis amastigotes (IC50 = 66.9 and 57.4 μM, respectively). The cytotoxicity of the compounds was assessed in BALB/c mouse peritoneal macrophages.
机译：对巴西Cerrado物种Clusia pernambucensis G.Mariz，Clusiaceae的茎皮中乙酸乙酯提取物的植物化学分析导致​​了新x吨酮1,7-二羟基-2-（3-甲基- 2-丁烯基）-6′，6′-二甲基吡喃（2′，3′：3，4）黄酮，即clusiaxanthone。还从该物种中分离了四种以前未报道的生育三烯酚。从clusiaxanthone，1-羟基，7-甲氧基-2-（3-甲基2-丁烯基）-6'，6'-二甲基吡喃（2'，3'：3,4）蒽酮（7-O-甲基clusiaxanthone）获得衍生物），并从Z-δ-生育三烯酚酸获得了另一种衍生物。这些化合物的结构基于1H和13C核磁共振（1D和2D NMR），高分辨率电喷雾电离质谱（HRESIMS）和红外光谱的数据建立。 clusiaxanthone及其衍生物能够控制利什曼原虫（Leishmania）amazonensis amastigotes的巨噬细胞感染（IC50分别为66.9和57.4μM）。在BALB / c小鼠腹膜巨噬细胞中评估了化合物的细胞毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号