Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

Alcides J. M. da Silva; Cláudia ó. Pessoa; Eduardo C. Torres-Santos; Arinice M. Costa; Gardenia C. G. Milit?o; Paulo R. R. Costa; Edézio F. Cunha-Junior; Letícia V. Costa-Lotufo; Sara L. S. Gomes

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Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

机译：3-碘代异黄酮和芳基硼酸之间的Suzuki-Miyaura偶联。具有抗肿瘤和抗利什曼活性的拉帕胆类似物的合成

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A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.

机译：通过3-碘代异黄酮与芳基硼酸/酯的Suzuki-Miyaura交叉偶联反应，合成了一系列2-羟基-3-芳基萘-1,4-二酮（3-芳基异丁烯）。将羟基化的所得产物转化为其相应的N，N-二乙基氨基甲酸酯。评估了该化合物的抗肿瘤和抗疟疾活性，并与拉帕酚及其氨基甲酸酯进行了比较，提供了可喜的结果。

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《Journal of the Brazilian Chemical Society》 |2017年第8期|共页
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Alcides J. M. da Silva; Cláudia ó. Pessoa; Eduardo C. Torres-Santos; Arinice M. Costa; Gardenia C. G. Milit?o; Paulo R. R. Costa; Edézio F. Cunha-Junior; Letícia V. Costa-Lotufo; Sara L. S. Gomes;
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1. Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities [J] . Gomes Sara L. S., Milit?￡o Gardenia C. G., Costa Arinice M., Journal of the Brazilian Chemical Society . 2017,第8期

机译：3-碘代异黄酮和芳基硼酸之间的Suzuki-Miyaura偶联。具有抗肿瘤和抗利什曼活性的拉帕胆类似物的合成
2. Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. [J] . Hocek M, Holy A, Votruba I, Journal of Medicinal Chemistry . 2000,第9期

机译：取代的6-苯基嘌呤碱基和核苷的合成及其细胞抑制活性：6-氯嘌呤衍生物与苯基硼酸的Suzuki-Miyaura交叉偶联反应的应用。
3. Antileishmanial activity of lapachol analogues [J] . Ant?nio Euzébio G Santana, Clariane S Correia, Gérzia Mc Machado, Memórias do Instituto Oswaldo Cruz . 2004,第7期

机译：拉帕胆类似物的抗利什曼活性
4. The Suzuki-Miyaura cross-coupling of chloroarenes with arylboronic acids in supercritical carbon dioxide [C] . Ilya V. Kuchurov, Andrei A. Vasiliev, Sergei G. Zlotin European Meeting on Supercritical Fluids . 2010

机译：超临界二氧化碳中芳基硼酸氯酮的铃木 - 宫系交叉偶联
5. Part I: Microwave-Assisted Continuous Flow Organic Synthesis (MACOS) and the Heck-type aminocarbonylation of aryl halides, and, the Suzuki-Miyaura cross-coupling of chloroformates. Part II: Structure-activity relationship (SAR) analysis of NHC-palladium PEPPSI complexes in aminations and cross-couplings [D] . Nasielski, Joanna 2009

机译：第一部分：微波辅助连续流动有机合成（MACOS）和芳基卤化物的Heck型氨基羰基化，以及氯甲酸酯的Suzuki-Miyaura交叉偶联。第二部分：胺和交叉偶联中NHC-钯PEPPSI复合物的结构-活性关系（SAR）分析
6. Direct One-Pot Synthesis of Primary 4-Amino-23-diaryl- quinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-azido-3-iodoquinolines with Arylboronic Acids [O] . Malose Jack Mphahlele, Mamasegare Mabel Mphahlele 2011

机译：通过2-芳基-4-叠氮基-3-碘喹啉与芳基硼酸的铃木-宫浦交叉偶合直接一锅合成伯4-氨基-23-二芳基-喹啉
7. Antileishmanial activity of lapachol analogues [O] . Nadja MF Lima, Clariane S Correia, Leonor L Leon, 2004

机译：拉帕胆类似物的抗利什曼活性

Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

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