Green Synthesis of Chalcones and Microbiological Evaluation

Alex F. C. Flores; Claudio M. P. Pereira; Juliana L. Malavolta; Marina Ritter; Rafael G. Lund; Rosiane M. Martins; Silvana A. Rosa

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Green Synthesis of Chalcones and Microbiological Evaluation

机译：al的绿色合成及微生物学评价

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A green method was developed for the synthesis of chalcones using glycerin as solvent. Subsequently, the potential microbiology activity of these molecules was evaluated by testing them against the Gram-positive bacteria Staphylococcus aureus (S. aureus) ATCC 19095 and Enterococcus faecalis (E. faecalis) ATCC 4083, the Gram-negative bacteria Escherichia coli (E. coli) ATCC 29214 and Pseudomonas aeruginosa (P. aeruginosa) ATCC 9027, and the fungus Candida albicans (C. albicans), which includes ATCC 62342 and three clinical strains of C. albicans from human oral cavities. The results showed that some chalcones exhibited moderate inhibitory activity, the most prominent being those acting against the fluconazole-resistant strains of C. albicans.

机译：开发了一种绿色方法，以甘油为溶剂合成查耳酮。随后，通过对革兰氏阳性细菌金黄色葡萄球菌（S. aureus）ATCC 19095和粪肠球菌（E. faecalis）ATCC 4083（革兰氏阴性细菌大肠埃希氏大肠杆菌（E.cherry））进行测试，评估了这些分子的潜在微生物活性。大肠埃希氏杆菌（ATCC 29214）和铜绿假单胞菌（P. aeruginosa）ATCC 9027，以及白色念珠菌（C. albicans）真菌，其中包括ATCC 62342和来自人口腔的三株白色念珠菌临床菌株。结果表明，一些查耳酮具有中等程度的抑制活性，其中最显着的是对白色念珠菌耐氟康唑的菌株起作用。

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《Journal of the Brazilian Chemical Society》 |2015年第6期|共10页
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Alex F. C. Flores; Claudio M. P. Pereira; Juliana L. Malavolta; Marina Ritter; Rafael G. Lund; Rosiane M. Martins; Silvana A. Rosa;
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中图分类生物物理学;
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机译：查尔酮的绿色合成与微生物评价

Green Synthesis of Chalcones and Microbiological Evaluation

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