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首页> 外文期刊>Journal of the Canadian Academy of Child and Adolescent Psychiatry >Clozapine Treatment and Cannabis Use in Adolescents with Psychotic Disorders – A Retrospective Cohort Chart Review
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Clozapine Treatment and Cannabis Use in Adolescents with Psychotic Disorders – A Retrospective Cohort Chart Review

机译：患有精神病的青少年使用氯氮平治疗和大麻使用-回顾性队列研究回顾

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Objectives: To examine the association between clozapine treatment and frequency of cannabis use in adolescentswith co-occurring psychotic and cannabis use disorder in a retrospective cohort chart review. Method: We conducted aretrospective cohort chart review of patients diagnosed with a psychotic disorder and concurrent cannabis use disorderadmitted to a tertiary care youth inpatient unit from 2010-2012. Longitudinal exposure and outcome data was coded monthby-month. Frequency of cannabis use was measured using a 7-point ordinal scale. Severity of psychosis was measuredon a 3-point ordinal scale. Mixed effects regression modeling was used to describe the relationship between exposureand outcome variables. Results: Thirteen patients had exposure to clozapine and fourteen had no exposure to clozapine.Cannabis use decreased in patients treated with clozapine, compared to patients treated with other antipsychotics (OR 2.8;95% CI 0.97-7.9). Compared to no medication, clozapine exposure was associated with significantly less cannabis use (OR7.1; 95% CI 2.3-22.3). Relative to treatment with other antipsychotics, clozapine exposure was significantly associated withlower severity of psychotic symptoms (OR 3.7; 95% CI 1.2-11.8). Conclusions: Clozapine may lead to decreased cannabisuse and psychotic symptoms in adolescents with concurrent psychosis and substance use. Clinical trials are warranted.
机译：目的：通过回顾性队列研究，探讨氯氮平治疗与青少年精神病和大麻使用并发的青少年大麻使用频率之间的关系。方法：我们对2010-2012年入院的三级医疗青年住院病房诊断为精神病性障碍和并发大麻使用障碍的患者进行了回顾性队列研究。纵向暴露和结局数据按月编码。大麻的使用频率以7点顺序量表进行测量。精神病的严重程度以3点顺序量表进行测量。混合效应回归模型用于描述暴露和结果变量之间的关系。结果：接受氯氮平治疗的有13名患者，没有氯氮平治疗的有14名患者。与其他抗精神病药物治疗的患者相比，接受氯氮平治疗的患者的大麻使用减少（OR 2.8; 95％CI 0.97-7.9）。与不使用药物相比，氯氮平暴露与使用大麻的次数明显减少有关（OR7.1; 95％CI 2.3-22.3）。相对于其他抗精神病药物治疗，氯氮平暴露与较低的精神病症状严重程度相关（OR 3.7; 95％CI 1.2-11.8）。结论：氯氮平可能导致青少年的大麻滥用和精神病症状减少，并伴有精神病和药物滥用。临床试验是必要的。

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