• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacopsychiatry >Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review.
【24h】

Aripiprazole as an adjunct to clozapine therapy in adolescents with early-onset schizophrenia: a retrospective chart review.

机译：阿立哌唑作为氯氮平治疗青少年精神分裂症青少年的辅助治疗：回顾性图表回顾。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Combination of antipsychotic substances is a therapeutic option increasingly applied in patients with schizophrenia, who do not respond to antipsychotic monotherapy. Recently, various reports on combination of clozapine with aripiprazole in adults have been published. As there is not yet data on adolescent patients, we aimed to study the above-mentioned augmentation strategy in this population. METHODS: We included 15 patients with schizophrenia from a child and adolescent psychiatric department (8 male; mean age 19.3 [SD+/-1.2, range 17.2-21.2] years). Patients had been under clozapine treatment, followed by aripiprazole augmentation. Retrospectively, patients' medical records were reviewed, using a rating scale in analogy to the Clinical Global Impressions (CGI) scale. RESULTS: Mean observation time was 11.1 [SD+/-9.7] months. Mean CGI-Severity scores improved significantly (p=0.003, d=0.76) from 5.3 (baseline) to 4.5 (endpoint; last observation carried forward (LOCF)). CGI-Improvement scores decreased from 3.7 (after 1 month) to 3.3 (endpoint; LOCF) (p=0.212, d=0.45). CONCLUSIONS: In adolescents with schizophrenia, aripiprazole augmentation of clozapine treatment might be an effective therapeutic strategy. Prospective studies for this age group are required to obtain more specific clinical data on clinical effectiveness.
机译：简介：抗精神病药物的结合是一种治疗选择，越来越多地应用于精神分裂症患者，他们对抗精神病药物的单一疗法无反应。最近，关于氯氮平与阿立哌唑在成人中联合使用的各种报道已经发表。由于尚无有关青少年患者的数据，我们旨在研究上述人群中的上述增强策略。方法：我们纳入了来自儿童和青少年精神科的15位精神分裂症患者（8位男性;平均年龄19.3 [SD +/- 1.2，范围17.2-21.2]岁）。患者已接受氯氮平治疗，随后进行阿立哌唑增强治疗。回顾性地，使用类似于临床总体印象（CGI）量表的评分量表对患者的病历进行审查。结果：平均观察时间为11.1 [SD +/- 9.7]个月。平均CGI严重性评分从5.3（基线）提高到4.5（终点;上一次观察结转（LOCF）），显着改善（p = 0.003，d = 0.76）。 CGI改善得分从3.7（1个月后）降低到3.3（端点; LOCF）（p = 0.212，d = 0.45）。结论：在精神分裂症青少年中，阿立哌唑增强氯氮平治疗可能是一种有效的治疗策略。需要对该年龄组进行前瞻性研究，以获得有关临床有效性的更具体的临床数据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号