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首页> 外文期刊>Journal of the Brazilian Chemical Society >Further dibromotyrosine-derived metabolites from the marine sponge Aplysina caissara
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Further dibromotyrosine-derived metabolites from the marine sponge Aplysina caissara

机译：海洋海绵Aplysina caissara的其他二溴酪氨酸衍生代谢产物

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The re-investigation of the crude extract obtained from the sponge Aplysina caissara led to the isolation of five new dibromotyrosine derivatives, named agelocaissarines A1, A2, B1, B2 and caissarine C, along with the already known fistularin-3 and 11-hydroxyaerothionin. All compounds were identified by analysis of mono- and bidimensional NMR spectra, high resolution mass spectra, infrared and ultraviolet spectra. The relative stereochemistry of agelocaissarines could be established by analysis of 1H NMR spectra and molecular modeling, while the absolute configuration of the spiroxazolidine moieties of fistularin-3, caissarine C and 11-hydroxyaerothionin was established by analysis of 1H NMR and circular dichroism spectra. Fistularin-3 and 11-hydroxyaerothionin displayed moderate antibiotic activity against several pathogenic bacteria.
机译：对从海绵Aplysina caissara提取的粗提物进行的重新研究导致分离出五种新的二溴酪氨酸衍生物，分别称为agelocaissarines A1，A2，B1，B2和caissarine C，以及已知的fistularin-3和11-hydroxyaerothionin。所有化合物均通过一维和二维NMR光谱，高分辨率质谱，红外和紫外光谱进行鉴定。可以通过1H NMR光谱分析和分子建模来确定agelocaissarines的相对立体化学，而通过1H NMR和圆二色性光谱分析可以确定fistularin-3，caissarine C和11-hydroxyaerothionin的螺恶唑烷部分的绝对构型。 Fistularin-3和11-hydroxyaerothionin对几种病原菌表现出中等的抗生素活性。

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