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首页> 外文期刊>Journal of the Brazilian Chemical Society >Further dibromotyrosine-derived metabolites from the marine sponge Aplysina caissara
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Further dibromotyrosine-derived metabolites from the marine sponge Aplysina caissara

机译：海洋海绵Aplysina caissara的其他二溴酪氨酸衍生代谢产物

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摘要

The re-investigation of the crude extract obtained from the sponge Aplysina caissara led to the isolation of five new dibromotyrosine derivatives, named agelocaissarines A1, A2, B1, B2 and caissarine C, along with the already known fistularin-3 and 11-hydroxyaerothionin. All compounds were identified by analysis of mono- and bidimensional NMR spectra, high resolution mass spectra, infrared and ultraviolet spectra. The relative stereochemistry of agelocaissarines could be established by analysis of H-1 NMR spectra and molecular modeling, while the absolute configuration of the spiroxazolidine moieties of fistularin-3, caissarine C and 11-hydroxyaerothionin was established by analysis of H-1 NMR and circular dichroism spectra. Fistularin-3 and 11-hydroxyaerothionin displayed moderate antibiotic activity against several pathogenic bacteria.
机译：对从海绵Aplysina caissara获得的粗提物进行的重新研究导致分离出五种新的二溴酪氨酸衍生物，分别命名为agelocaissarines A1，A2，B1，B2和caissarine C，以及已知的fistularin-3和11-羟空硫醚素。通过分析一维和二维NMR光谱，高分辨率质谱，红外和紫外光谱来鉴定所有化合物。可以通过分析H-1 NMR谱图和分子模型来确定agelocaissarines的相对立体化学，而通过H-1 NMR和圆环图可以确定fistularin-3，caissarine C和11-羟基高硫基硫辛的螺恶唑烷部分的绝对构型。二向色光谱。 Fistularin-3和11-hydroxyaerothionin对几种病原菌表现出中等的抗生素活性。

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