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首页> 外文期刊>Journal of the Canadian Academy of Child and Adolescent Psychiatry >Sensitivity of Scales to Evaluate Change in Symptomatology with Psychostimulants in Different ADHD Subtypes
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Sensitivity of Scales to Evaluate Change in Symptomatology with Psychostimulants in Different ADHD Subtypes

机译：量表评估精神障碍药物在多动症亚型中症状变化的敏感性

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Objective: To assess the sensitivity of scales (Conners’ Global Index Parent and Teacher form [CGI-P, CGI-T], Clinical Global Impression Scale [CGI], Continuous Performance Test [CPT], and Restricted Academic Situation Scale [RASS]) in evaluating improvement in symptomatology with methylphenidate in different Attention Deficit Hyperactivity Disorder (ADHD) subtypes. Method: Four hundred and ninety children (309 with ADHD Combined/Hyperactive [ADHD-CH] and 181 with ADHD Inattentive subtype [ADHD-I]) participated in a two week double-blind placebo-controlled crossover methylphenidate trial. Results: CGI-P showed small effect size for ADHD-I and medium effect size for the ADHD-CH subtype. CGI-T showed medium effect size for ADHD-I and large effect size for ADHD-CH subtype. CGI and RASS showed large effect size while CPT showed medium effect size for both subtypes. Conclusion: Acute behavioural assessments by clinicians (CGI, RASS) are better at detecting improvement with medication in all subtypes than parent or teacher reports (CGI-P, CGI-T). CGI-T is better than CGI-P for ADHD-I in detecting change in symptomatology as there is a greater demand for attention at school.
机译：目的：评估量表的敏感性（康纳斯全球指数父母和老师的形式[CGI-P，CGI-T]，临床总体印象量表[CGI]，持续表现测验[CPT]和限制性学习状况量表[RASS] ）评估哌替啶在不同的注意力缺陷多动障碍（ADHD）亚型中症状的改善。方法：490名儿童（309名ADHD合并/多动性[ADHD-CH]和181名ADHD不专心亚型[ADHD-I]的儿童）参加了为期两周的双盲安慰剂对照交叉哌醋甲酯试验。结果：CGI-P对ADHD-1的影响较小，对ADHD-CH亚型的影响中等。 CGI-T对ADHD-1表现出中等的效应大小，对ADHD-CH亚型表现出大的效应大小。对于这两种亚型，CGI和RASS均显示出较大的效应量，而CPT显示出中等的效应量。结论：与父母或老师的报告（CGI-P，CGI-T）相比，临床医生（CGI，RASS）进行的急性行为评估更能更好地发现所有亚型药物的改善情况。 CGI-T在检测症状变化方面优于ADHD-1的CGI-P，因为在学校对注意力的需求更大。

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