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首页> 外文期刊>Journal of the International Association of Providers of AIDS Care. >Single-Boosted Protease Inhibitor versus Double-Boosted Protease Inhibitors for the Salvage Therapy in HIV-Infected Patients
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Single-Boosted Protease Inhibitor versus Double-Boosted Protease Inhibitors for the Salvage Therapy in HIV-Infected Patients

机译：单助蛋​​白酶抑制剂与双助蛋白酶抑制剂在HIV感染患者中的挽救治疗

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Objective: To compare treatment outcomes between the regimens of single-boosted protease inhibitor (PI) and double-boosted PIs for the salvage therapy in patients who failed nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens. Methods: A total of 64 patients from 2 cohorts, 40 in twice daily ritonavir-boosted lopinavir (LPV/r) at 400/100 mg plus lamivudine (3TC) and 24 in once daily ritonavir-boosted atazanavir and saquinavir (ATV/SQV/r) at 300/1600/100 mg/d, were studied. Results: At 48 weeks, 30 (75%) patients in LPV/r group and 20 (83%) patients in ATV/SQV/r group achieved HIV-1 RNA at 400 copies/mL (P = .790). In all, 24 (60%) and 16 (67%) achieved HIV-1 RNA at 50 copies/mL (P = .541). Low-level viral rebound (51-400 copies/mL) was found in 6 (15%) in LPV/r group and 4 (17%) in ATV/SQV/r group (P = 1.000). Medians CD4 counts were 336 cells/mm3 and 330 cells/mm3 in the corresponding groups (P = 0.937). Conclusion: No additional benefit is found with double-boosted PIs compared to single-boosted PI in terms of treatment responses in HIV-infected patients failing NNRTI-based regimen.
机译：目的：比较基于非核苷类逆转录酶抑制剂（NNRTI）方案的挽救性治疗的单效蛋白酶抑制剂（PI）和双效PI方案之间的治疗效果。方法：来自2个队列的64例患者，其中40例在每日两次利托那韦增强的洛匹那韦（LPV / r）中以400/100 mg加拉米夫定（3TC）服用，而24​​例在利托那韦增强的阿扎那韦和沙奎那韦（ATV / SQV / r）以300/1600/100 mg / d的浓度进行了研究。结果：在第48周，LPV / r组的30名患者（75％）和ATV / SQV / r组的20名患者（83％）的HIV-1 RNA含量<400拷贝/ mL（P = .790）。总共有24个（60％）和16个（67％）的HIV-1 RNA浓度低于<50拷贝/ mL（P = .541）。 LPV / r组中有6例（15％）和ATV / SQV / r组中有4例（17％）发现低水平的病毒反弹（51-400拷贝/ mL）（P = 1.000）。相应组中的CD4计数中位数为336细胞/ mm3和330细胞/ mm3（P = 0.937）。结论：在以NNRTI为基础的治疗方案失败的HIV感染患者中，与单升效PI相比，双升效PI没有发现更多益处。

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