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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Serum reference value of two potential doping candidates—myostatin and insulin-like growth factor-I in the healthy young male
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Serum reference value of two potential doping candidates—myostatin and insulin-like growth factor-I in the healthy young male

机译：在健康的年轻男性中，两种潜在的兴奋剂候选物（肌生长抑制素和胰岛素样生长因子-I）的血清参考值

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BackgroundMyostatin negatively regulates muscle growth, and its inhibition by suitable proteins can increase muscle bulk and exercise performance. However, the reference values of serum myostatin in athletes performing strength training are still lacking. MethodsA cross-sectional study?recruiting28 male collegiate athletes performing strength training and 29 age-matched normal controls?was conducted.The serum concentration of myostatin and insulin-like growth factor 1 (IGF-1), grip strength, and body composition were the main outcome measures. We used regression models to analyze the correlation between serum markers and the physiological parameters. The athlete group had greater height, weight, body mass index (BMI), fat mass percentage, fat-free mass, muscle mass, waist girth, grip strength, and estimated daily energy expenditure. ResultsThe IGF-1 concentration was higher in the athlete group (324?±?80 vs. 263?±?134?ng/ml), but the myostatin levels did not differ (12.1?±?3.7 vs. 12.4?±?3.5?ng/ml). The reference value for IGF-1 among the healthy young males was 293?±?114?ng/ml, correlated with age and height; the value for myostatin was 12.3?±?3.6?ng/ml, correlated negatively with BMI, fat mass percentage, and waist girth after adjustment for age. ConclusionMyostatin level is negatively related to fat percentage, and serum IGF-1 is positively related to height. The reference values could provide a basis for future doping-related study.
机译：背景Myostatin负面地调节肌肉的生长，其被合适的蛋白质抑制会增加肌肉的体积和运动能力。但是，仍缺乏进行力量训练的运动员血清肌生成抑制素的参考值。方法采用横断面研究方法，招募28名大学生进行强度训练，并与29名年龄相匹配的正常对照组进行研究，其中血清肌生长抑制素和胰岛素样生长因子1（IGF-1）的浓度，握力和身体成分为主要观察指标。我们使用回归模型来分析血清标志物和生理参数之间的相关性。运动组的身高，体重，体重指数（BMI），脂肪质量百分比，无脂肪质量，肌肉质量，腰围，抓地力和估计的每日能量消耗更高。结果运动员组的IGF-1浓度较高（324？±？80 vs. 263？±？134？ng / ml），但肌生长抑制素水平没有差异（12.1？±？3.7 vs. 12.4？±？3.5 ？ng / ml）。健康青年男性中IGF-1的参考值为293？±？114？ng / ml，与年龄和身高相关。调整年龄后，肌肉生长抑制素的值为12.3±±3.6？ng / ml，与BMI，脂肪质量百分比和腰围呈负相关。结论肌生长抑制素水平与脂肪百分比呈负相关，血清IGF-1与身高呈正相关。参考值可以为将来与掺杂有关的研究提供基础。

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