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首页> 外文期刊>Journal of Young Pharmacists >Spasmolytic Activity of Fruits of Tamarindus indica L.
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Spasmolytic Activity of Fruits of Tamarindus indica L.

机译:罗望子果果实的痉挛活性。

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Objective: To study the possible effects of methanolic extract of fruits of Tamarindus indica on rabbit’s jejunum preparations. Materials and Methods: The study was carried out on rabbit’s jejunum preparations. Methanolic extract of fruits of T. indica was applied in different doses. Potassium chloride (KCl 80 mM)-induced contractions were relaxed by the extract. For determination of possible mode of action of relaxing effects, calcium chloride curves were constructed in decalcified tissues using K+ normal and followed by K+ rich solution. The curves were then compared with verapamil. Results: Relaxant effects on KCl-induced contractions were prominent at a concentration of 5.0-10.0 mg/ml (P50 ± SEM = 1.98 ± 0.03) and 10.0 mg/ml (EC50 ± SEM = 1.79 ± 0.05) versus control (EC50 ± SEM = 2.33 ± 0.058) resembled the effects of verapamil on the calcium chloride curves. Conclusion: The results confirmed its possible mode of relaxing effects i.e. through calcium channel blockade.
机译:目的:研究罗望子果果实甲醇提取物对家兔空肠制剂的影响。材料和方法:该研究是针对兔子的空肠制剂进行的。 T树果实的甲醇提取物以不同剂量施用。提取液可以放松氯化钾(KCl 80 mM)诱导的收缩。为了确定松弛作用的可能作用方式,使用正常的K + 在脱钙的组织中绘制氯化钙曲线,然后添加富含K + 的溶液。然后将曲线与维拉帕米进行比较。结果:在5.0-10.0 mg / ml(P50 ±SEM = 1.98±0.03)和10.0 mg / ml(EC 50 ± SEM = 1.79±0.05)vs对照(EC 50 ±SEM = 2.33±0.058)与维拉帕米对氯化钙曲线的影响相似。结论:结果证实了其可能的放松作用方式,即通过钙通道阻滞。

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