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首页> 外文期刊>Journal of Young Pharmacists >Investigation of the mechanisms underlying the gastroprotective effect of Cymbopogon citratus essential oil
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Investigation of the mechanisms underlying the gastroprotective effect of Cymbopogon citratus essential oil

机译：香柏柠檬精油胃肠保护作用机理的研究

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Cymbopogon citratus is a medicinal plant popularly used in Brazil for the treatment of various diseases, and the research interest in this plant is justifiable because of its potential medicinal value in stomachache and gastric ulcer. This study was aimed to test the validity of this practice by using experimental models of gastric ulcer and to clarify the mechanisms of gastroprotection by C. citratus leaves essential oil (EOCC). EOCC was evaluated for the ability to protect the gastric mucosa against injuries caused by necrotizing agents (absolute ethanol and aspirin) in rodents. The results of this study revealed that EOCC posses a dose-independent anti-ulcer effect against the different experimental models. EOCC pretreatment depicted a higher preventive index in ethanol-(88%) and aspirin-induced (76%) acute ulceration. On pretreatment of mice with indomethacin, the cyclooxygenase inhibitor slightly suppressed the gastroprotective effect of EOCC (48.5%). Furthermore, EOCC gastroprotection was not attenuated in mice pretreated with L-NAME (85.2%), glibenclamide (100%), or yohimbine (79.7%), the respective inhibitors of nitric oxide synthase, K + ATP channel activation, and α2 receptors. These results confirmed the traditional use of C. citratus for the treatment of gastric ulcer. Thus, we provide the first evidence that EOCC reduces gastric damage induced by ethanol, at least in part, by mechanisms that involve endogenous prostaglandins.
机译：Cymbopogon citratus是在巴西广泛用于治疗各种疾病的药用植物，由于其在胃痛和胃溃疡中的潜在药用价值，对该植物的研究兴趣是合理的。这项研究旨在通过使用胃溃疡的实验模型来检验这种做法的有效性，并阐明柠檬酸梭菌叶精油（EOCC）对胃的保护作用。评估了EOCC保护啮齿动物胃粘膜免受坏死剂（无水乙醇和阿司匹林）伤害的能力。这项研究的结果表明，EOCC对不同的实验模型具有剂量依赖性的抗溃疡作用。 EOCC预处理对乙醇（88％）和阿司匹林诱导的（76％）急性溃疡具有更高的预防指数。用吲哚美辛预处理小鼠后，环氧合酶抑制剂会轻微抑制EOCC的胃保护作用（48.5％）。此外，在分别用一氧化氮合酶，K + ATP的抑制剂L-NAME（85.2％），格列本脲（100％）或育亨宾（79.7％）预处理的小鼠中，EOCC的胃保护作用没有减弱。通道激活和α 2 受体。这些结果证实了柠檬酸梭菌在治疗胃溃疡中的传统用途。因此，我们提供了第一个证据，即EOCC至少部分地通过涉及内源性前列腺素的机制减轻了乙醇引起的胃损伤。

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