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首页> 外文期刊>Journal of Young Pharmacists >Chitosanepectin polyelectrolyte complex as a carrier for colon targeted drug delivery
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Chitosanepectin polyelectrolyte complex as a carrier for colon targeted drug delivery

机译：壳聚糖聚合物电解质复合物作为结肠靶向药物输送的载体

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Objective: The objective of present work was to prepare a polyelectrolyte complex (PEC) between chitosan (polycation) & pectin (polyanion) and to develop enteric coated tablets for colon delivery using the PEC. Methodology: The PECs were prepared using different concentrations of chitosan and pectin. Drug loaded enteric coated tablets were prepared by wet granulation method using PEC to sustain the release at colon and coating was done with Eudragit S 100 to prevent the early release of the drug in stomach and intestine. Two independent variable, % PEC (chitosan/pectin) and % coating were optimized by 32 full factorial design. Statistical model were also used to supplement the optimization. DSC was performed to confirm the interaction between the polyions. Developed formulations were evaluated for physical appearance, weight variation, thickness, hardness, friability, % swelling, assay, in-vitro and ex-vivo drug release studies to investigate the PEC’s ability to deliver the drug to colon. Ex-vivo release study using rat caecal content was also carried out on optimized formulation. Results and discussion: DSC results confirmed chitosan/pectin interaction and subsequent formation of PEC. The optimized formulation containing 1.1% of PEC and 3% of coating showed highest swelling and release in alkaline pH mechanism of which was found to be microbial enzyme dependent degradation established by ex-vivo study using rat caecal content
机译：目的：目前的工作目的是制备壳聚糖（聚阳离子）和果胶（聚阴离子）之间的聚电解质复合物（PEC），并开发使用该PEC的肠溶片剂。方法：用不同浓度的壳聚糖和果胶制备PEC。载有药物的肠溶衣片剂通过湿法制粒制备，使用PEC维持结肠的释放，并用Eudragit S 100进行包衣，以防止药物在胃和肠中的早期释放。通过32个全因子设计优化了两个独立变量PEC百分比（壳聚糖/果胶）和涂层百分比。统计模型也用于补充优化。进行DSC以确认聚离子之间的相互作用。对开发的制剂进行了物理外观，重量变化，厚度，硬度，脆性，溶胀度，溶出度，测定，体外和离体药物释放研究的评估，以研究PEC将药物递送至结肠的能力。还使用了大鼠盲肠内容物进行了体外释放研究，以优化配方。结果与讨论：DSC结果证实了壳聚糖/果胶的相互作用以及随后形成的PEC。含有1.1％PEC和3％涂层的优化配方在碱性pH值下表现出最高的溶胀和释放，其机理是通过使用大鼠盲肠含量的离体研究确定了微生物酶依赖性降解

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