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首页> 外文期刊>Journal of Viruses >Hepatitis B Virus Seroprevalence and Serology Patterns in a Cohort of HIV Positive Individuals from Harare, Zimbabwe
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Hepatitis B Virus Seroprevalence and Serology Patterns in a Cohort of HIV Positive Individuals from Harare, Zimbabwe

机译：一群来自津巴布韦哈拉雷的HIV阳性个体的乙型肝炎病毒血清流行率和血清学模式

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Zimbabwe is highly endemic for hepatitis B virus (HBV) and also has high human immunodeficiency virus (HIV) prevalence rates which may result in HIV/HBV coinfection, and as HIV/HBV coinfection may affect the classical HBV serology patterns and cause interpretation challenges, we assessed the seroprevalence of HBV in HIV positive patients and determined their serology profiles. This was a cross-sectional study on 957 HIV positive specimens from treatment naive patients. HBV serology tests were done using enzyme immunoassays for the detection of HBV markers in human serum or plasma. Hepatitis B surface antigen (HBsAg) prevalence was 17.1% (males 19.0%, females 15.8%). Previous and/or current HBV exposure was evident in 59.8% of the patients and hepatitis B e antigen markers were present in 103 (10.8%) specimens. There was high prevalence of unusual HBV patterns with 14.1% of total specimens showing an anti-HBc alone profile and an additional 4.3% HBsAg positive specimens that were anti-HBc negative.
机译：津巴布韦是乙型肝炎病毒（HBV）的高度流行病，也有很高的人类免疫缺陷病毒（HIV）患病率，可能导致HIV / HBV合并感染，并且由于HIV / HBV合并感染可能影响经典的HBV血清学模式并引起解释挑战，我们评估了HIV阳性患者的HBV血清阳性率，并确定了他们的血清学特征。这是对来自未治疗患者的957例HIV阳性样本的横断面研究。 HBV血清学测试使用酶免疫法进行，用于检测人血清或血浆中的HBV标记。乙型肝炎表面抗原（HBsAg）患病率为17.1％（男性19.0％，女性15.8％）。 59.8％的患者先前和/或当前的HBV暴露很明显，而103份（10.8％）的样本中存在B型肝炎e抗原标记。异常HBV模式的患病率很高，占全部标本的14.1％显示出单独的抗HBc特征，另有4.3％的HBsAg阳性标本为抗HBc阴性。

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