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首页> 外文期刊>Journal of Young Pharmacists >Hepatocurative Effect of Saussurea lappa C.B Clarke and Artemisia absinthium, Linn in Chronic Hepatitis B
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Hepatocurative Effect of Saussurea lappa C.B Clarke and Artemisia absinthium, Linn in Chronic Hepatitis B

机译：雪莲雪茄C.B Clarke和艾蒿苦艾对慢性乙型肝炎的肝治愈作用

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Objective: Repeated immune attacks in chronic hepatitis B produce recurrent inflammation in the liver and render it to develop fibrous tissue and carcinoma. Hence, present study aims to evaluate the hepatocurative effect of qust ( Saussurea lappa ) and afsanteen ( Artemisia absinthium ) in the chronic hepatitis B patients. Method: In a single arm pilot clinical study, 30 patients of chronic hepatitis B with ALT (alanine aminotransferase) 2 times of upper limit of normal were treated with decoction of qust ( Saussurea lappa ) and decoction of afsanteen ( Artemisia absinthium ) daily orally for 3 months. Patients were evaluated for liver function test at baseline, 6th week and 12th week of treatment. Result: Test drug reduced the mean serum bilirubin, ALT, AST highly significantly at 12th week of treatment. (p Conclusion: We reviewed the literature related to the test drug, Saussurea lappa and Artemisia absinthium used for the treatment in these cases. The observed hepatocurative effect could be due anti-inflammatory, hepatoprtotective, antioxidant and immunomodulator properties of these drugs, substantiated in various animal studies. These findings indicate the hepatocurative effect of Saussurea lappa and Artemisia absinthium in chronic hepatitis B cases. Randomized controlled clinical studies should be conducted to explore the further efficacy.
机译：目的：慢性乙型肝炎的反复免疫攻击会在肝脏中反复发作炎症，使其发展为纤维组织和癌。因此，本研究旨在评估在慢性乙型肝炎患者中，山茱sure（Sussurea lappa）和苦艾酒（Afsanteen）（苦艾蒿）的肝硬化作用。方法：在单臂先导临床研究中，对每天30例ALT（丙氨酸氨基转移酶）>正常上限的2倍的慢性乙型肝炎患者，分别用奎斯特汤（Sussurea lappa）和苦参（Artemisia absinthium）汤治疗3个月。在治疗的基线，治疗的第6周和第12周对患者进行肝功能测试。结果：试验药物在治疗第12周时显着降低了平均血清胆红素，ALT，AST。 （p结论：我们回顾了有关在这些情况下用于治疗的试验药物，雪莲和苦艾蒿的相关文献。观察到的肝硬化作用可能是由于这些药物的抗炎，保肝，抗氧化和免疫调节特性所致，这些发现表明雪莲和青蒿对慢性乙型肝炎的肝硬化作用，应进行随机对照临床研究以探讨进一步的疗效。

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