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首页> 外文期刊>Journal of Young Pharmacists >Retrospective Qualitative and Quantitative Analysis of Adverse Events Following Vaccination
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Retrospective Qualitative and Quantitative Analysis of Adverse Events Following Vaccination

机译：接种疫苗后不良事件的回顾性定性和定量分析

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Background: Vaccination is an essential component of the public health programs. A small minority of persons may experience mild, time limited adverse reactions, however, in rare cases, it may be serious. Hence there is a need of a surveillance program to monitor, record and analyze adverse event following immunization (AEFI). Method: All AEFIs in year 2015-2016 reported to NCC-PvPI were included in analysis. The data were entered in Excel sheet and analyzed for age group, gender, reporter detail, month wise reporting, seriousness, suspected vaccine and body system organ classification. Quality of AEFI was checked by completeness score as per WHO criteria. Result: The NCC-PvPI received 637 reports with 794 AEFIs. Majority of AEFIs were noted in infants (55%) and the main source of AEFI reporters were physicians (88%).The quality of reports were satisfactory with average completeness score 0.88. Category “body as a whole” (48.49%) was the commonest clinical manifestation and most common AEFI was fever (43.95%). DPT/Haemophilus influenza type B/Polio vaccine was most common causal vaccine (n=155). Approximately 13% AEFIs were serious in nature with seven deaths. Conclusion: The system of AEFI reporting in India is slowly gaining momentum. Majority of AEFIs were mild. However, serious AEFI needs detail reporting, follow up, investigation for causality assessment and identify risk factors. Organized training of health care professionals in AEFI reporting and targeted spontaneous reporting of vaccine AEFI will be helpful in this regard.
机译：背景：疫苗接种是公共卫生计划的重要组成部分。少数人可能会遇到轻微的，时间有限的不良反应，但是在极少数情况下，它可能很严重。因此，需要一种监视程序来监视，记录和分析免疫接种后的不良事件（AEFI）。方法：将2015-2016年向NCC-PvPI报告的所有AEFI纳入分析。将数据输入Excel表格并分析其年龄，性别，报告人详细信息，按月报告，严重性，可疑疫苗和身体系统器官分类。根据WHO标准，通过完整性评分检查AEFI的质量。结果：NCC-PvPI收到637份AEFI的报告637份。婴儿中AEFI占大多数（55％），AEFI报道者的主要来源是医生（88％），报告质量令人满意，平均完整性评分为0.88。类别“整体”（48.49％）是最常见的临床表现，而最常见的AEFI是发烧（43.95％）。 DPT / B型流感嗜血杆菌/脊髓灰质炎疫苗是最常见的因果疫苗（n = 155）。大约13％的AEFI本质上是严重的，有7人死亡。结论：印度的AEFI报告系统正在缓慢地发展。多数AEFI轻微。但是，严重的AEFI需要详细报告，跟进，调查因果关系评估并确定风险因素。在这方面，对保健专业人员进行有关AEFI报告和针对性自发报告疫苗AEFI的有组织培训将是有帮助的。

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