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首页> 外文期刊>Journal of Young Pharmacists >Clinical Trial of Nanoencapsulated Centella asiatica and Zingiber officinale to Improve Cellulite and Subcutaneous Adipolysis
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Clinical Trial of Nanoencapsulated Centella asiatica and Zingiber officinale to Improve Cellulite and Subcutaneous Adipolysis

机译：纳米囊积积雪草和姜黄改善脂肪团和皮下脂肪分解的临床试验

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Objective: The purpose of this study was to determine the effect of nanoencapsulated Centella asiatica and Zingiber officinale extract, with the dose of 3000 mg/day, in reducing cellulite and improving the composition of subcutaneous adipose. Methods: This study used the quasi-experimental with pre and post-controlled design using 38 female subjects who suffer cellulite and have BMI 25, and met the inclusion and exclusion criteria. Subjects were grouped randomly into the 28-day treatment group, the 42-day treatment group, and control group. Subjects in the treatment groups received the tested herbal with 3000 mg/day (2 x 3 capsules @500 mg) that should be taken in determined duration. Appearance of cellulite and lipid profile were observed and body composition analysis was performed before and after treatment. Data were analyzed using T-test, Wilcoxon or Mann-Whitney, while the comparison of the three treatment groups was tested with ANOVA with 95% confidence level (p Results: The administration of the drug for 28 days can significantly repair the cellulite grade. There was a significant improvement in cholesterol/HDL ratio, which showed that the 28-day treatment group was better than the 42-day treatment group. Compared to control group, the 28-day and the 42-day treatment groups showed better clinical improvements in total cholesterol, LDL, the ratio of LDL/HDL, fasting blood sugar, weight, BMI, body fat, body fat percentage, left and right arm fat, trunk fat, left thigh fat, and cellulite grade. Conclusion: Nanoencapsulated extract of C. asiatica and Z. officinale can improve cellulite, lipid profile, and subcutaneous fat.
机译：目的：本研究的目的是确定3000毫克/天的纳米胶囊积雪草和姜提取物在减少脂肪和改善皮下脂肪组成方面的作用。方法：本研究采用准实验设计的前后对照设计，研究对象为38名患有脂肪团且BMI> 25且符合纳入和排除标准的女性受试者。将受试者随机分为28天治疗组，42天治疗组和对照组。治疗组中的受试者接受了3000 mg /天（2 x 3胶囊@ 500 mg）的测试草药，应在确定的持续时间内服用。观察脂肪团的外观和脂质分布，并在治疗前后进行身体成分分析。使用T检验，Wilcoxon或Mann-Whitney分析数据，而三个治疗组的比较用ANOVA进行，可信度为95％（p结果：给药28天可显着修复橘皮组织等级。胆固醇/高密度脂蛋白比值有显着改善，表明28天治疗组优于42天治疗组，与对照组相比，28天和42天治疗组表现出更好的临床改善总胆固醇，低密度脂蛋白（LDL），低密度脂蛋白/高密度脂蛋白（LDL / HDL）的比例，空腹血糖，体重，BMI，体脂，体脂百分比，左右臂脂肪，躯干脂肪，左大腿脂肪和脂肪团等级。 C.asiatica和Z.officinale可以改善脂肪团，脂质分布和皮下脂肪。

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