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首页> 外文期刊>Journal of Young Pharmacists >Comparison of the Characteristics of Transfersomes and Protransfersomes Containing Azelaic Acid
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Comparison of the Characteristics of Transfersomes and Protransfersomes Containing Azelaic Acid

机译：含壬二酸的传递体和前传递体的特性比较

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Objective: Recently developed agent carriers, transfersomes, which are sufficiently deformable to penetrate into or across the skin barrier. Protransfersome is the lyophilization of transfersome by removing the water system with freeze-drying method to improve the protransfersome characterizations, especially entrapment efficiency. The aim of this study was to comparethe characteristics ofazelaic acid transfersomes and protransfersomes. Method: Transfersome was prepared by thin layer hidration method. Protransfersome was prepared by freeze-drying method and trehalose as lyoprotectant. The characterizations that measured were entrapment efficiency, morphological structure, particle size, and zeta potential. Result: The result of Transfersome particel size characterization, pointed out measurement with 89,06 nm. Whereas, after freeze- drying process, Protransfersome A has 735 nm, Protransfersome B has 1218 nm, and Protransfersome C has723,1 nm. There are excalations from 40,98% of entrapment efficiency after freeze-drying process, Protransfersome A with percentage 45,20%, Protransfersome B with percentage 45,65%, and Protransfersome C with percentage 52,90%. The spheric vesicle morphology of transfersome and protransfersomes is determined by transmission electron microscope. Conclusion: Protransfersomes have a better stability in entrapment efficiency by using trehalose or no trehalose with indirect cooling rate within 4 weeks of storage period.
机译：目的：最近开发的药物载体，传递体，可充分变形以穿透或穿透皮肤屏障。前转移体是通过冻干法去除水系统以改善前转移体的特性，特别是截留效率，从而将转移体冻干。本研究的目的是比较壬二酸转移体和前转移体的特性。方法：采用薄层隐蔽法制备传递体。用冷冻干燥法制备海藻糖作为脯氨酸保护剂。测量的特征是包封率，形态结构，粒度和ζ电势。结果：Transfersome颗粒尺寸表征的结果，指出在89,06 nm处进行测量。冷冻干燥后，Protransfersome A的波长为735 nm，Protransfersome B的波长为1218 nm，Propropsome C的波长为723.1 nm。冷冻干燥后的包封效率为40.98％，Protransfersome A占45.20％，Protransfersome B占45.65％，Protransfersome C占52.90％。通过透射电子显微镜确定转移体和转移前体的球形囊泡形态。结论：在贮存期4周内，使用间接冷却速率的海藻糖或不使用海藻糖，前传体具有更好的包封效率。

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