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首页> 外文期刊>Journal of Young Pharmacists >Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives
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Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

机译：某些3b-羟基-lup-20（29）-en-28-油酸衍生物的合成及生物评价

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Objective: The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also investigated. Method: BA derivatives were prepared by conjugating 3b-Hydroxy-lup- 20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay. Results: Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively. Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.
机译：目的：本研究计划合成3b-羟基-lup-20（29）-en-28-油酸类似物，以评估其可能的生物学活性。此外，还研究了结构-活性关系。方法：通过羰基连接将3b-羟基-lup-20（29）-en-28-oic酸与不同的胺缀合，制备BA衍生物。通过光谱数据阐明了合成化合物的结构。通过CAM测定法和MTT测定法进行细胞毒性评价。结果：在合成的化合物中，化合物7在抗血管生成试验以及化合物ECV-304细胞系中显示出明显的细胞毒性。化合物10也显示出良好的细胞毒性活性。而化合物6和8分别显示出对A-549和MCF-7的中等活性。结论：结论是合成的BA类似物具有生物活性，并已发展成为有用的抗癌药。

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