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首页> 外文期刊>Journal of Young Pharmacists >Allantoin Alleviates Male Sexual Dysfunction in Diabetic Rats through Augmenting the Level of Testosterone
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Allantoin Alleviates Male Sexual Dysfunction in Diabetic Rats through Augmenting the Level of Testosterone

机译：尿囊素通过增加睾丸激素的水平来减轻糖尿病大鼠的男性性功能障碍。

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Objective: A majority of the diabetic patients experience sexual dysfunction. The objective of the study was to investigate the effect of allantoin on sexual dysfunction in diabetic rats. Methods: Streptozotocin-induced diabetic Wistar rats were divided into 3 groups: diabetic control group, diabetes + allantoin 100 mg/kg and diabetes + allantoin 200 mg/kg. Diabetic rats were treated with allantoin for 6 weeks and were assessed for its effect on sexual behavior, blood pressure, sperm count, sperm morphology, and levels of glycosylated hemoglobin, serum testosterone, and nitrite. Effects of treatment on diabetic rats were compared with diabetic control rats and normal healthy rats. Results: Diabetes decreased sexual behavior, sperm count and levels of serum testosterone and nitrite while increased blood pressure, the level of glycosylated hemoglobin and sperm defects in comparison to healthy rats. After a 6-week treatment period, there was a significant decrease in glycosylated hemoglobin (HbA1C) and blood pressure in the allantoin treatment groups when compared to diabetic control. Also, the rats treated with allantoin performed significantly well in sexual behavioural studies with a significant increase in body weight, sperm count, and levels of serum testosterone and nitrite compared to diabetic control. Conclusion: Oral administration of allantoin improves sexual function in diabetic rats by improving glycemic control and maintaining blood pressure. It also improves sexual function in diabetic rats by preventing the reduction in levels of nitrite and serum testosterone.
机译：目的：大多数糖尿病患者都患有性功能障碍。该研究的目的是研究尿囊素对糖尿病大鼠性功能障碍的影响。方法：链脲佐菌素诱导的糖尿病Wistar大鼠分为3组：糖尿病对照组，糖尿病+尿囊素100 mg / kg和糖尿病+尿囊素200 mg / kg。用尿囊素治疗糖尿病大鼠6周，并评估其对性行为，血压，精子数量，精子形态以及糖基化血红蛋白，血清睾丸激素和亚硝酸盐水平的影响。将治疗对糖尿病大鼠的效果与糖尿病对照大鼠和正常健康大鼠进行比较。结果：与健康大鼠相比，糖尿病降低了性行为，精子数量以及血清睾丸激素和亚硝酸盐水平，而血压，糖基化血红蛋白水平和精子缺陷增加。经过6周的治疗后，与糖尿病对照组相比，尿囊素治疗组的糖基化血红蛋白（HbA1C）和血压显着降低。此外，与糖尿病对照组相比，尿囊素治疗的大鼠在性行为研究中表现良好，体重，精子数量以及血清睾丸激素和亚硝酸盐水平显着增加。结论：口服尿囊素可通过改善血糖控制和维持血压来改善糖尿病大鼠的性功能。它还通过防止亚硝酸盐和血清睾丸激素水平的降低来改善糖尿病大鼠的性功能。

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