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首页> 外文期刊>Journal of Young Pharmacists >Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia
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Antioxydant and Endotheliotropic Properties 4-Hydroxy-3,5-Di-Tret-Butyl Cinnamic Acid under Conditions of Experimental Brain Ischemia

机译：实验性脑缺血条件下的4-羟基-3,5-二叔丁基肉桂酸的抗氧化和促内皮性质

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Objective: To assess the effect of 4-hydroxy-3,5-di-tret-butyl cinnamic acid on the state of endothelial function under conditions of experimental cerebral ischemia. Materials and Methods: Antioxidant properties of 4-hydroxy-3,5-di-tret-butyl cinnamic acid and the effect of this compound on NO-synthase system activity and ADMA concentration were evaluated. Results: As a result, it has been found that the use of 4-hydroxy-3,5-di-tretbutyl cinnamic acid promotes reduction activity of catalase, glutathione peroxidase, superoxide dismutase and a decrease in the concentration of MDA and DC. In addition, the ability to modulate NO synthase system activity was established for this compound: an increase in eNOS activity by 114.2% ( p <0.05), decrease activity of nNOS and iNOS by 60.6% ( p <0.05) and 61.9% ( p <0.05), respectively, decrease concentration of ADMA by 83.9% ( p <0.05). Conclusion: The results of the conducted researches it is established that 4-hydroxy-3,5-di-tret-butyl cinnamic acid has antioxidant and NOS - regulating effect.
机译：目的：评价4-羟基-3,5-二叔丁基肉桂酸在实验性脑缺血条件下对内皮功能状态的影响。材料与方法：评估了4-羟基-3,5-二叔丁基肉桂酸的抗氧化性能以及该化合物对NO合酶体系活性和ADMA浓度的影响。结果：结果发现，使用4-羟基-3,5-二叔丁基肉桂酸可促进过氧化氢酶，谷胱甘肽过氧化物酶，超氧化物歧化酶的还原活性以及MDA和DC浓度的降低。此外，该化合物具有调节NO合酶系统活性的能力：eNOS活性提高114.2％（p <0.05），nNOS和iNOS活性降低60.6％（p <0.05）和61.9％（p <0.05）分别使ADMA浓度降低了83.9％（p <0.05）。结论：进行的研究结果表明，4-羟基-3,5-二叔丁基肉桂酸具有抗氧化和调节NOS的作用。

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