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首页> 外文期刊>Journal of Young Pharmacists >Prevalence of Antimicrobial Resistant Pathogens in Severe Sepsis and Septic Shock Patients
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Prevalence of Antimicrobial Resistant Pathogens in Severe Sepsis and Septic Shock Patients

机译：严重脓毒症和脓毒性休克患者中耐药菌病的发生率

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Emergence of antimicrobial resistance is turning to be a life threatening problem in the treatment of patients with severe sepsis and septic shock. Many organisms display a multidrug resistant (MDR) pattern, which limits the treatment options. Aim: The purpose of this study was to assess the prevalence of pathogens including the resistant types causing severe sepsis and septic shock as well as their antimicrobial resistance patterns. Methods: This was a prospective, observational study conducted at emergency department of a tertiary care hospital. A total of 293 bacterial isolates obtained during April 2015-16 inclusive, from severe sepsis and septic shock patients underwent susceptibility testing. Results: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Candida non-albicans were the most common organisms.With respect to the specimen source, majority of the isolates (38.6%) were obtained from urine specimens followed by blood (27%), skin/soft tissue specimen (16.4%) and respiratory specimen (15%). Escherichia coli showed good susceptibility to amikacin, meropenem and piperacillin-tazobactam. Klebsiella pneumoniae showed high rates of resistance to all the tested antimicrobials except colistin. The MDR phenotype occurred in 24.6% Escherichia coli , 30.4% Pseudomonas aeruginosa , 56.4% Klebsiella pneumoniae and 87.5% Acinetobacter baumannii. No resistance was seen among fungal isolates. Conclusion: Our results highlight the high prevalence of gram negative organisms among severe sepsis and septic shock patients in south India. Strict implementation of sepsis guidelines, right antibiotic selection and dosage will help in preventing the development of resistance.
机译：在患有严重败血症和败血性休克的患者的治疗中，抗菌素耐药性的出现已成为威胁生命的问题。许多生物表现出耐多药（MDR）模式，这限制了治疗选择。目的：本研究的目的是评估病原体的流行情况，包括引起严重败血症和败血性休克的耐药类型，以及其耐药模式。方法：这是在三级医院急诊科进行的一项前瞻性观察性研究。在2015年4月至16日（含）期间，对来自严重败血症和败血性休克患者的293株细菌进行了药敏试验。结果：大肠杆菌，肺炎克雷伯菌，铜绿假单胞菌，白色念珠菌和非白色念珠菌是最常见的微生物，在标本来源方面，大多数分离株（38.6％）取自尿液标本，其次是血液（27％） ），皮肤/软组织样本（16.4％）和呼吸道样本（15％）。大肠杆菌对丁胺卡那霉素，美洛培南和哌拉西林-他唑巴坦表现出良好的敏感性。肺炎克雷伯菌显示对大肠菌素以外的所有测试抗药性都有很高的耐药性。 MDR表型发生在24.6％的大肠杆菌，30.4％的铜绿假单胞菌，56.4％的肺炎克雷伯菌和87.5％的鲍曼不动杆菌中。在真菌分离株中未观察到耐药性。结论：我们的结果突出了印度南部严重败血症和败血性休克患者中革兰氏阴性菌的高流行。严格执行败血症指南，正确选择抗生素和剂量将有助于预防耐药性的发展。

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