Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance

Stephen Y. Liang; An Kumar

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Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance

机译：严重脓毒症和感染性休克的经验性抗菌疗法：优化病原体清除率

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Mortality and morbidity in severe sepsis and septic shock remain high despite significant advances in critical care. Efforts to improve outcome in septic conditions have focused on targeted, quantitative resuscitation strategies utilizing intravenous fluids, vasopressors, inotropes, and blood transfusions to correct disease-associated circulatory dysfunction driven by immune-mediated systemic inflammation. This review explores an alternate paradigm of septic shock in which microbi-al burden is identified as the key driver of mortality and progression to irreversible shock. We propose that clinical outcomes in severe sepsis and septic shock hinge upon the optimized selection, dosing, and delivery of highly potent antimicrobial therapy.

机译：尽管重症监护取得了重大进展，但严重败血症和败血性休克的死亡率和发病率仍然很高。在脓毒症中改善结局的努力集中在利用静脉输液，升压药，正性肌力药物和输血来纠正由免疫介导的全身性炎症驱动的疾病相关循环功能障碍的靶向，定量复苏策略。这篇评论探讨了败血性休克的另一种范式，其中微生物负荷被确定为死亡率和不可逆性休克发展的关键驱动力。我们建议严重败血症和败血性休克的临床结果取决于优化的高效抗菌治疗的选择，给药和给药。

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《Current infectious disease reports.》 |2015年第8期|共1页
作者
Stephen Y. Liang; An Kumar;
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正文语种 eng
中图分类传染病;
关键词
Septic shock; Sepsis; Infection; Antimicrobial Antibiotic; Pharmacokinetics; Combination therapy; Survival;

机译：败血性休克;败血症;感染;抗菌抗生素;药代动力学;联合治疗;生存;

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1. Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance [J] . Stephen Y. Liang, An Kumar Current infectious disease reports. . 2015,第7a8期

机译：严重脓毒症和感染性休克的经验性抗菌疗法：优化病原体清除率
2. Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. [J] . Jones AE Chest: The Journal of Circulation, Respiration and Related Systems . 2011,第6期

机译：要点：是否应采用乳酸清除率代替中心静脉血氧饱和度作为早期严重脓毒症和脓毒性休克治疗的目标？是。
3. Counterpoint: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? No. [J] . Rivers EP, Elkin R, Cannon CM Chest: The Journal of Circulation, Respiration and Related Systems . 2011,第6期

机译：应对措施：是否应采用乳酸清除清除中心静脉血氧饱和度作为早期严重脓毒症和脓毒性休克治疗的目标？没有。
4. Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock [C] . Papaioannou V.P., Dragoumanis C.D., Pneumatikos I.P. Computers in Cardiology, 2009 . 2009

机译：严重败血症和败血性休克患者心率变异性与血清C反应蛋白水平的关系
5. Fluid bolus administration in early goal directed therapy treatment of severe sepsis and septic shock in the emergency department: predictors and outcomes [D] . Williams, Jennifer A. 2014

机译：在急诊科室进行的早期目标定向治疗严重脓毒症和脓毒性休克的液体推注给药：预测因素和结果
6. Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance [O] . Stephen Y. Liang, Anand Kumar -1

机译：严重脓毒症和感染性休克的经验性抗菌疗法：优化病原体清除率
7. Considerations for Empiric Antimicrobial Therapy in Sepsis and Septic Shock in an Era of Antimicrobial Resistance [O] . Jeffrey R Strich, Emily L Heil, Henry Masur 2020

机译：在抗菌性时代脓毒症和脓毒症抗检伤中的经验性抗菌治疗的考虑因素

Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance

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