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首页> 外文期刊>Journal of Young Pharmacists >Preparation and Characterization of Microcrystalline Cellulose Produced from Betung Bamboo (Dendrocalamus asper) through Acid Hydrolysis
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Preparation and Characterization of Microcrystalline Cellulose Produced from Betung Bamboo (Dendrocalamus asper) through Acid Hydrolysis

机译：酸水解必通竹（Dendrocalamus asper）微晶纤维素的制备与表征

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Introduction: Microcrystalline cellulose (MCC) is an excipient used in food, cosmetics and pharmaceutical industries especially in the manufacture of tablet. Dendrocalamus asper (betung bamboo) contains high cellulose content at approximately 44.94% and it has potential as raw material of microcrystalline cellulose. Objective: The purpose of this study was to obtain microcrystalline cellulose powder from betung bamboo and it’s physicochemical properties. Methods: The steps to produce microcrystalline cellulose were extraction with n-Hexane: Ethanol (2:1), isolation of alpha cellulose, and acid hydrolysis of alpha cellulose to MCC. The purity of microcrystalline cellulose obtained was identified by infrared spectrophotometry and melting point determination. Other characteristics such as x-ray diffraction, particle size distribution, pH, ash content, moisture content, loss on drying, flow rate, density, scanning electron microscope, and angle of repose were also determined and compared to Avicel PH 101. Results: The Infra-red spectrum obtained were similar to reference Avicel PH 101. The powder was moderately fine, odorless, tasteless and less white compared to reference, particle size distribution 1117.4 nm, pH 6.88, ash contents ± 0.0584%, moisture content 36%, loss on drying 4.59%. Density, flow rate and angle of repose fulfilled the requirements based on the literature. Conclusion: There is a similarity characteristic of MCC obtained and reference. So, there is a possibility for its use as excipient in the future by doing the application studies in food and pharmacy.
机译：简介：微晶纤维素（MCC）是一种赋形剂，用于食品，化妆品和制药行业，尤其​​是片剂生产中。 Dendrocalamus asper（竹炭竹）的纤维素含量高，约为44.94％，具有作为微晶纤维素原料的潜力。目的：本研究的目的是从竹笋中提取微晶纤维素粉及其理化性质。方法：制备微晶纤维素的步骤是用正己烷：乙醇（2：1）萃取，分离α纤维素以及将α纤维素酸水解为MCC。通过红外分光光度法和熔点测定来鉴定获得的微晶纤维素的纯度。还确定了其他特性，例如X射线衍射，粒度分布，pH，灰分，水分，干燥失重，流速，密度，扫描电子显微镜和休止角。并将其与Avicel PH 101进行了比较。所获得的红外光谱与参比品Avicel PH 101相似。与参比品相比，该粉末略微细腻，无味，无味且白色较少，粒度分布为1117.4 nm，pH为6.88，灰分为±0.0584％，水分为36％，干燥失重4.59％。根据文献，密度，流速和休止角均满足要求。结论：获得的MCC与参考文献具有相似性。因此，通过在食品和制药中的应用研究，将来有可能将其用作赋形剂。

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