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首页> 外文期刊>Journal of Young Pharmacists >A Case Report on Linezolid and Cefuroxime Induced Leucocytoclastic Vasculitis
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A Case Report on Linezolid and Cefuroxime Induced Leucocytoclastic Vasculitis

机译：利奈唑胺和头孢呋辛致白细胞碎裂性血管炎的一例报道

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A 65-year-old female diabetic patient with wet gangrene on left great toe developed skin eruptions and blebs over her limbs and lower abdomen after receiving three doses of tablet linezolid + cefuroxime (600mg+500 mg). The skin eruptions and blebs completely resolved fourteen days after discontinuation of tablet Linezolid+ Cefuroxime. Based on her presentation (Skin eruptions and blebs), we consider that the condition was a result of linezolid+ cefuroxime administration. While the pathophysiology of these cutaneous reactions is not completely understood, clinicians should be vigilant to allow early detection of these problems. The causality of this adverse reaction was determined by using Naranjo’s criteria and World Health Organization Probability scale and was found to be possible and the severity of this reaction was determined by using the Modified Hartwig and Siegel scale and was found to be moderate (Level 3b) reaction. Although, Linezolid is known to cause dermatological reactions like rashes but the reports of leucocytoclastic vasculitis are rare. Thus, our case report of linezolid+ cefuroxime induced leucocytoclastic vasculitis add newer information. Physician should be vigilant for the potential of drug to cause some rare side-effect like leucocytoclastic vasculitis on similar age groups, so that a safer alternative treatment can be started.
机译：一名65岁的女性糖尿病患者，左脚趾上有坏疽，在接受三剂利奈唑胺+头孢呋辛酯（600mg + 500 mg）剂量治疗后，在其四肢和小腹出现皮肤爆发和起泡。片剂Linezolid +头孢呋辛酯停药后十四天，皮肤爆发和起泡完全消失。根据她的表现（皮肤爆发和起泡），我们认为该病是利奈唑胺+头孢呋辛酯给药的结果。尽管尚未完全了解这些皮肤反应的病理生理学，但临床医生应保持警惕，以便及早发现这些问题。使用Naranjo的标准和世界卫生组织的概率量表确定了该不良反应的因果关系，并发现是可能的，并且使用改良的Hartwig和Siegel量表确定了该反应的严重程度，发现为中等程度（3b级）反应。尽管已知利奈唑胺会引起皮疹等皮肤病反应，但很少有关于白细胞碎裂性血管炎的报道。因此，我们的利奈唑胺+头孢呋辛肟诱导的白细胞碎裂性血管炎的病例报告增加了新的信息。医生应警惕药物可能在类似年龄组引起一些罕见的副作用，如白细胞碎裂性血管炎，以便可以开始更安全的替代治疗。

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