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首页> 外文期刊>Journal of Young Pharmacists >Anthocyanin-rich Buni-berry (Antidesma bunius) Extract Increases Paraoxonase 1 Gene Expression in BALB/c Mice Fed with a High-fat Diet
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Anthocyanin-rich Buni-berry (Antidesma bunius) Extract Increases Paraoxonase 1 Gene Expression in BALB/c Mice Fed with a High-fat Diet

机译：富含花青素的黑莓（Antidesma bunius）提取物可提高高脂饮食喂养的BALB / c小鼠对氧磷酶1基因的表达

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Objective: The aim of this study was to determine the effectiveness of buni-berry ( Antidesma bunius ) extract to increase PON1 mRNA expression in BALB/c mice fed with a high-fat diet. Methods: Twenty, thirty-weeks old male BALB/c mice were randomly allocated into four intervention groups; buni berry extract, simvastatin, control-sick and control-normal groups. All groups received high fat diet, except control-normal group which received control normal-diet. The diets were provided for 12 weeks. Treatments were started in all groups at the same time with the administration of the diets. Mice in buni-berry group were treated with oral buni-berry 300 mg/kgBW/day. In simvastatin group the mice were provided with oral simvastatin 6 mg/kkBW/day. The mice in control-sick and control-normal group were not received additional treatment. The intervention was conducted in 12 weeks. Mice body weight was measured weekly. Blood samples from tails were examined at the baseline and after12 weeks intervention for PON1 mRNA expression. Expression of PON1 mRNA was analysed by quantitative Real Time Polymerase Chain Reaction (qRT-PCR) . Results: The changes mice body weights during interventions in all groups were not significantly different. PON1 mRNA expression was significantly increase in the buni berry extract group and simvastatin group, while in control-sick group the expression was significantly reduced. Conclusion: Oral administration of 300 mg/kgBW/day of buni-berry extract is effectively increases PON1 expression in BALB/c mice fed with a high fat diet.
机译：目的：本研究的目的是确定Buni-berry（Antidesma bunius）提取物增加高脂饮食喂养的BALB / c小鼠中PON1 mRNA表达的有效性。方法：将20只30周龄的雄性BALB / c小鼠随机分为四个干预组。布尼浆果提取物，辛伐他汀，对照组和正常对照组。除正常对照组外，所有组均接受高脂饮食。提供饮食12周。所有组在开始饮食的同时开始治疗。布尼浆果组的小鼠口服布尼浆果300 mg / kgBW /天。在辛伐他汀组，给小鼠口服辛伐他汀6mg / kkBW /天。对照组和正常对照组的小鼠没有接受额外的治疗。干预在12周内进行。每周测量小鼠体重。在基线和干预12周后检查尾巴的血样中PON1 mRNA的表达。通过定量实时聚合酶链反应（qRT-PCR）分析PON1mRNA的表达。结果：各组干预期间小鼠体重变化无明显差异。布尼浆果提取物组和辛伐他汀组中PON1 mRNA表达显着增加，而对照病组中PON1 mRNA表达显着降低。结论：每天口服300 mg / kgBW的Buni-berry提取物可以有效地提高高脂饮食喂养的BALB / c小鼠中PON1的表达。

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