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首页> 外文期刊>Journal of Young Pharmacists >Induction of Epithelial Ovarian Cancer by Implantation of 7,12-dimethylbenz(a)athracene (DMBA) Coated Silk in Rats.
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Induction of Epithelial Ovarian Cancer by Implantation of 7,12-dimethylbenz(a)athracene (DMBA) Coated Silk in Rats.

机译：在大鼠中植入7,12-二甲基苯并（a）蒽（DMBA）涂层的丝诱导上皮性卵巢癌。

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Objective: This research aims to get the relevant animal model for epithelial ovarian cancer and ultrasonography approach to detect volume and size of ovarian cancer. Methods: Induction of ovarian cancer in rats was carried out using 7,12-Dimethylbenz [a] anthracene (DMBA) coated on silk suture and then implanted in the left ovary of female Wistar rats. Nodule were determined weekly after the first surgery by palpating the abdominal wall of rats. Utrasonography was carried out at 20supth/sup week. Rats were euthanized, ovarian organs were taken and histopathological examination was performed with haematoxylin and eosin staining. Results: Nodules in DMBA-treated rats were noted at 16supth/sup weeks post implantation and reaching a cummulative incidence of 96, 4% at 24supth/sup weeks. On ultrasound examination at the 20th week, there were significant differences in left and right ovarian size and volume. The histological type of induced tumor included: serous carcinoma cell, clear cell carcinoma, sarcoma and squamous carcinoma. Conclusion: The implanted 7,12-Dimethylbenz[a]anthracene (DMBA) coated silk suture in the ovaries rats can be used as animal model for testing therapeutics agent of ephitelial ovarian cancer and ultrasonography can determine the size and volume of tumors formed in ovary.
机译：目的：本研究旨在建立上皮性卵巢癌的相关动物模型，并通过超声检查方法检测卵巢癌的大小和大小。方法：采用丝线缝合的7,12-二甲基苯并[a]蒽（DMBA），然后将其植入雌性Wistar大鼠的左卵巢，以诱导大鼠卵巢癌。首次手术后每周通过触诊大鼠腹壁确定结节。超声检查在第20周进行。将大鼠安乐死，取卵巢器官，并用苏木精和曙红染色进行组织病理学检查。结果：DMBA处理的大鼠在植入后第16周发现结节，在植入后第24周达到累积发生率96，4％。在第20周进行超声检查时，左右卵巢的大小和体积存在明显差异。诱发肿瘤的组织学类型包括：浆液性癌细胞，透明细胞癌，肉瘤和鳞状癌。结论：在卵巢大鼠中植入7,12-二甲基苯并[a]蒽（DMBA）涂层丝线可作为测试上皮性卵巢癌治疗剂的动物模型，超声检查可确定卵巢中形成的肿瘤的大小和体积。

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