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首页> 外文期刊>Gynecologic Oncology: An International Journal >Ovarian neoplasm development by 7,12-dimethylbenz(a)anthracene (DMBA) in a chemically-induced rat model of ovarian failure.
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Ovarian neoplasm development by 7,12-dimethylbenz(a)anthracene (DMBA) in a chemically-induced rat model of ovarian failure.

机译：在化学诱导的卵巢功能衰竭大鼠模型中，由7,12-二甲基苯并（a）蒽（DMBA）开发卵巢肿瘤。

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OBJECTIVES: The objectives were to determine the time course for ovarian failure in rats caused by 4-vinylcyclohexene diepoxide (VCD) and develop a model for ovarian cancer in which ovarian neoplasms were chemically induced in an animal that was follicle depleted, but retained residual ovarian tissue. METHODS: Initially, female Fisher 344 rats were treated with VCD (to induce ovarian failure) or vehicle control (sesame oil). Three or 6 months after treatment, ovaries were collected and processed for histological evaluation for confirmation of ovarian failure. A further set of female rats was assigned to four groups exposed to combinations of vehicle control, VCD and/or DMBA (directly applied to the ovary) in a novel model for examining early stages of ovarian neoplasia. RESULTS: Three and 6 months following VCD dosing there was a significant reduction of ovarian weight and follicle number. Treatment with DMBA subsequent to VCD resulted in tumors in 42% of animals at 3 months and 57% at 5 months. All neoplasms were classified Sertoli-Leydig cell tumors (SLCT). No tumor occurred in animals treated with vehicle or DMBA alone. CONCLUSIONS: These studies demonstrate that the VCD-treated rat can be used as a model for peri- and post-menopause. DMBA induction of ovarian neoplasms was greater in those rats treated with VCD. Whether this increase was due to tumor initiation by VCD or was the result of ovarian failure cannot be distinguished from these results. This represents the only animal model to date for sex cord stromal tumors.
机译：目的：目的是确定由4-乙烯基环己烯二环氧化合物（VCD）引起的大鼠卵巢衰竭的时程，并开发一种卵巢癌模型，在该模型中以化学方式诱导了卵泡耗尽但保留了残留卵巢的动物卵巢肿瘤组织。方法：最初，雌性Fisher 344大鼠接受VCD（诱发卵巢衰竭）或媒介物对照（芝麻油）治疗。治疗后三到六个月，收集卵巢并进行处理以进行组织学评估，以确认卵巢功能衰竭。在用于检查卵巢赘生物早期阶段的新模型中，将另一组雌性大鼠分为暴露于媒介物对照，VCD和/或DMBA（直接应用于卵巢）的组合的四个组。结果：VCD给药后3个月和6个月，卵巢重量和卵泡数目明显减少。 VCD后用DMBA进行治疗在3个月时导致42％的动物出现肿瘤，在5个月时导致57％的动物出现肿瘤。所有肿瘤均被分类为Sertoli-Leydig细胞肿瘤（SLCT）。单独用赋形剂或DMBA治疗的动物中没有发生肿瘤。结论：这些研究表明，用VCD治疗的大鼠可以用作绝经前后的模型。 VCD处理的那些大鼠中，DMBA对卵巢肿瘤的诱导作用更大。这些增加是由于VCD引发的肿瘤引起，还是由于卵巢衰竭引起的。这代表了迄今为止唯一的性索间质肿瘤动物模型。

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