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首页> 外文期刊>Journal of Young Pharmacists >Assessment of Success Rate of Directly Observed Treatment Short-Course (DOTS) in Tuberculosis Patients of South India
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Assessment of Success Rate of Directly Observed Treatment Short-Course (DOTS) in Tuberculosis Patients of South India

机译：印度南部结核病患者直接观察治疗短期课程（DOTS）成功率的评估

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Objective: To assess the success rate of DOTS for tuberculosis patients and the secondary objective was to identify the factors associated with unsuccessful treatment outcome. Methods: A retrospective study was conducted to review the medical records of patients (n = 1113) registered at the Directly Observed Treatment Short-Course (DOTS) clinic of Government Infectious Disease (Govt. ID) Hospital, Guntur, India. Multivariate logistic regression model was used to determine the factors associated with the treatment success rate. Results: The overall mean success rate of TB patients was found to be 82.8%. Treatment success rate (TSR) was steadily increased across the years from 73.9% in 2015 to 84.3% in 2016 and 88.9% in 2017 while the death rate was steadily decreased from 11.2% in 2015 to 6.25% in 2016 and 4.33% in 2017. Risk factors significantly associated with unsuccessful treatment outcome were found to be HIV positive (P0.001), smear negative ( P 0.001), all retreatment cases ( P 0.001), smoking ( P =0.008), and alcoholism (P=0.019). Smear positive patients had lower death rate (3.9% vs. 10.1%; P 0.001) and failure rate ((2.6% vs. 8.7%; P 0.001) compared to smear negative patients. Patients tested HIV positive had seen significantly unfavorable outcomes in death rate (OR= 9.17, 95% CI=5.31-15.83; P 0.001) and treatment failure (OR=13.3, 95% CI= 7.31-24.17; P 0.001). Conclusion: Implementing the DOTS strategy proved the satisfactory success rate in the South Indian hospital across three years. The unsuccessful treatment outcome was significantly associated with gender, HIV status, re-treatment, smear negative, smoking and alcoholism.
机译：目的：评估DOTS在结核病患者中的成功率，其次要目的是确定与治疗结果不成功相关的因素。方法：进行了一项回顾性研究，回顾了印度古图尔政府传染病医院（Govt。ID）在直接观察治疗短程（DOTS）诊所登记的患者（n = 1113）的病历。使用多元逻辑回归模型确定与治疗成功率相关的因素。结果：发现结核病患者的总体平均成功率为82.8％。多年来，治疗成功率（TSR）从2015年的73.9％稳步增加到2016年的84.3％和2017年的88.9％，而死亡率则从2015年的11.2％稳步下降到2016年的6.25％和2017年的4.33％。与未成功治疗结果显着相关的危险因素被发现为HIV阳性（P <0.001），涂片阴性（P <0.001），所有再治疗病例（P <0.001），吸烟（P = 0.008）和酗酒（P = 0.019） ）。与涂片阴性患者相比，涂片阳性患者的死亡率（3.9％vs. 10.1％; P <0.001）和失败率（（2.6％vs. 8.7％; P <0.001）更低。死亡率（OR = 9.17，95％CI = 5.31-15.83; P <0.001）和治疗失败（OR = 13.3，95％CI = 7.31-24.17; P <0.001）。结论：实施DOTS策略证明是令人满意的南印度医院三年来的成功率，治疗失败与性别，艾滋病毒感染状况，再治疗，涂片阴性，吸烟和酗酒密切相关。

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