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首页> 外文期刊>Journal of Young Pharmacists >Phytochemical screening, Antioxidant, Thrombolytic, alpha-amylase inhibition and cytotoxic activities of ethanol extract of Steudnera colocasiifolia K. Koch leaves
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Phytochemical screening, Antioxidant, Thrombolytic, alpha-amylase inhibition and cytotoxic activities of ethanol extract of Steudnera colocasiifolia K. Koch leaves

机译：拟南芥乙醇提取物的植物化学筛选，抗氧化，血栓溶解，α-淀粉酶抑制和细胞毒活性

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Objective: Present study aims to investigate both qualitative and quantitative phytochemicals presence, antioxidant, thrombolytic, α-amylase and cytotoxic activity of a Bangladeshi plant Steudnera colocasiifolia K. Koch leaf ethanolic extract. Methods: Phytochemical screening was accomplished by using established methods. Thrombolytic assay was conducted through clot lysis method. Alpha amylase inhibition assay was made by modified enzyme inhibitory action and cytotoxicity was studied by brine shrimp lethality test. Data was analyzed by One Way Analysis of Variance (ANOVA) using statistical software Statistical Package for Social Science (SPSS, Version 22.0, IBM corporation, NY) followed by student ‘t’ test with GraphPad Prism Data Editor for Windows, Version 6.0 (GraphPad software Inc., San Diego, CA). Results: Primary screening shows the presence of major metabolites such as alkaloid, flavonoid, tannin, saponins, steroid, quinone, cellulose and glycosides while the quantitative analysis elicits the presence of magnificent amount of flavonoid (70.60 ± 0.23), proanthocyanidin (64.46 ± 0.58), flavonol (71.22 ± 0.07) and total antioxidant (66.40 ± 0.26) in the extract. The thrombolytic effect of S. colocasiifolia was found to be 35.16% and this extract had good α-amylase inhibitory activity (IC50=2.16 ± 0.06 mg/ml) as compared to Acarbose. The extract was found to have a LC50 value of 305.2 μg/ml in Brine shrimp lethality bioassay. Conclusion: Results demonstrate the Steudnera colocasiifolia has a very good prospect to be studied further for its extended antioxidative and α-amylase inhibitory effects.
机译：目的：本研究旨在研究孟加拉植物Steudnera colocasiifolia K. Koch叶乙醇提取物的定性和定量植物化学物质的存在，抗氧化剂，血栓溶解，α-淀粉酶和细胞毒活性。方法：采用既定方法进行植物化学筛选。通过血块溶解法进行溶栓测定。通过改进的酶抑制作用进行α淀粉酶抑制试验，并通过盐水虾杀伤力试验研究其细胞毒性。使用统计软件用于社会科学的统计软件包（SPSS，版本22.0，IBM公司，纽约）通过单方差分析（ANOVA）分析数据，然后使用GraphPad Prism Data Editor for Windows版本6.0（GraphPad）进行学生't'检验软件公司，加利福尼亚州圣地亚哥）。结果：初步筛选显示存在主要代谢产物，如生物碱，类黄酮，单宁，皂角苷，类固醇，醌，纤维素和糖苷，而定量分析表明存在大量的类黄酮（70.60±0.23），原花青素（64.46±0.58） ），提取物中的黄酮醇（71.22±0.07）和总抗氧化剂（66.40±0.26）。发现沙门氏菌的溶栓作用为35.16％，与阿卡波糖相比，该提取物具有良好的α-淀粉酶抑制活性（IC 50 = 2.16±0.06 mg / ml）。在盐水虾致死性生物测定中，该提取物的LC 50 值为305.2μg/ ml。结论：结果表明，Steudnera colocasiifolia具有广泛的抗氧化和α-淀粉酶抑制作用，具有很好的应用前景。

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