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首页> 外文期刊>Journal of Young Pharmacists >Hordeum Vulgare Hull in the Design of Fast Disintegrating Tablets
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Hordeum Vulgare Hull in the Design of Fast Disintegrating Tablets

机译：大麦壳在快速崩解片的设计中

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In the present study, fast disintegrating tablets were designed with a view to enhance patient compliance. In this method, the hull of Hordeum vulgare, cross carmellose sodium, and sodium starch glycolate were used as superdisintegrants (4 and 6%), along with microcrystalline cellulose and mannitol, to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on the in vitro dispersion time, the formulations were tested for the in vitro drug release pattern. Tablets having H. vulgare hull showed the release profile comparable to those tablets having sodium starch glycolate and cross carmellose sodium.
机译：在本研究中，设计快速崩解片剂以增强患者的依从性。在这种方法中，大麦的外壳，羧甲基纤维素钠和羟乙酸淀粉钠与微晶纤维素和甘露醇一起用作超级崩解剂（4和6％），以增强口感。对所制备的片剂批次进行硬度，易碎性，药物含量均匀性，润湿时间，吸水率和体外分散时间的评估。基于体外分散时间，测试制剂的体外药物释放模式。具有低俗壳的片剂显示出与具有羟乙酸淀粉钠和交叉羧甲基纤维素钠的片剂相当的释放曲线。

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