...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Young Pharmacists >Pharmacological and Biochemical Interventions of Cigarette Smoke, Alcohol, and Sexual Mating Frequency on Idiopathic Rat Model of Parkinson’s Disease
【24h】

Pharmacological and Biochemical Interventions of Cigarette Smoke, Alcohol, and Sexual Mating Frequency on Idiopathic Rat Model of Parkinson’s Disease

机译：香烟烟雾，酒精和性交频率对帕金森病特发性大鼠模型的药理和生化干预

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Parkinson's Disease (PD) is a neurodegenerative disorder in the nigrostriatal pathway of animals and humans and is responsible for most of the movement disorders, including rigidity. The present study aimed to determine the effect of chronic cigarette smoke, alcohol intake, and frequent sexual mating on 1-Methyl-4-phenyl-1,2,3,6-tertahydro pyridine (MPTP)-induced rat model of PD. After treatment, the effect of these factors was determined by biochemical and molecular evaluation. Dopamine (DA) concentration, antioxidant enzymes, and mitochondrial activity decreased after treatment with cigarette smoke, alcohol, and frequent sexual mating when compared to the values in the control group. Excessive exposure of these factors may lead to neurodegeneration, dopaminergic toxicities, and, ultimately, clinical parkinsonism. Earlier literature from different publisher suggested that nicotine and cigarette smoke can protect the dopaminergic neurons in the substantia nigra against MPTP toxicity. In this study, we assessed the effect of the above three factors on an MPTP-treated rat model and concluded that they have a neurodegenerative effect and were found to be toxic to dopaminergic neurons in the substantia nigra. Further investigation is required to understand the exact etiology of clinical parkinsonism.
机译：帕金森氏病（PD）是动物和人类黑纹状体途径中的神经退行性疾病，是造成大多数运动障碍（包括僵硬）的原因。本研究旨在确定长期吸烟，饮酒和频繁性交对1-甲基-4-苯基-1,2,3,6-叔氢吡啶（MPTP）诱导的PD大鼠模型的影响。治疗后，通过生化和分子评估确定这些因素的作用。与对照组相比，用香烟烟雾，酒精和频繁的性交处理后，多巴胺（DA）浓度，抗氧化酶和线粒体活性降低。这些因素的过度暴露可能导致神经退行性变，多巴胺能毒性，并最终导致临床帕金森病。来自不同出版商的早期文献表明，尼古丁和香烟烟雾可以保护黑质中的多巴胺能神经元免受MPTP毒性。在这项研究中，我们评估了上述三个因素对MPTP处理的大鼠模型的影响，并得出结论，它们具有神经退行性作用，并且被发现对黑质中的多巴胺能神经元有毒性。需要进一步研究以了解临床帕金森病的确切病因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号