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首页> 外文期刊>Journal of Young Pharmacists >Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies
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Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies

机译：山竹果皮局部递送的自纳米乳化药物递送系统（Snedds）：制剂设计和体外研究

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Objective: Purpose of this research was to get the optimum formulation of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of mangosteen peels and to evaluate the permeation ability of active substances in the formulation. Method: Oil phase solubility of ethanol extract, ethyl acetate extract, ethyl acetate fraction, n-hexane fraction and residue of the mangosteen peels was tested with virgin coconut oil (VCO). The formulation was designed with a simplex lattice design using Design Expert software and the permeation was tested using Franz diffusion cell. Results: Based on the results of simplex lattice design methods obtained that the optimum formulation of SNEDDS was the composition of VCO, Tween 80, PEG 400 at a ratio of 1:6,95:2,05. The results of permeation test in vitro using Franz Diffusion cell indicated that the obtained SNEDDS ethyl acetate fraction of mangosteen peels that is 96.9223% higher than without preparation SNEDDS was 18,9426 % on hour-8. The optimum physical evaluation SNEDDS optimum values obtained involved drug loading of 125mg/5 mL SNEDDS, the transmittance value of 92%, emulsification time of 65 seconds, pH of 6.35, particle size 20 nm, zeta potential -12,40 and stable for three months. Conclusion: SNEDDS can improve the diffusion rate of mangosteen peels as a model poorly water soluble drug.Various samples of mangosteen peels were screened as candidates for SNEDDS on the basis of solubility of the active compound in oils, surfactants, and co-surfactants. Simplex lattice design methods can be used to obtain optimum formulation on SNEDDS.
机译：目的：本研究的目的是获得山竹果皮自纳米乳化药物递送系统（SNEDDS）的最佳配方，并评估该配方中活性物质的渗透能力。方法：用纯椰子油（VCO）测试乙醇提取物，乙酸乙酯提取物，乙酸乙酯馏分，正己烷馏分和山竹果皮残留物的油相溶解度。使用Design Expert软件以单晶格设计设计配方，并使用Franz扩散池测试渗透率。结果：基于获得的单纯形晶格设计方法的结果，SNEDDS的最佳配方为VCO，Tween 80，PEG 400的比例为1：6,95：2,05。用Franz扩散池进行的体外渗透测试结果表明，所获得的山竹果皮的SNEDDS乙酸乙酯分数比未制备SNEDDS时高96.9223％，在第8小时为18,9426％。获得的最佳物理评估SNEDDS最佳值包括125 mg / 5 mL SNEDDS的载药量，透光率值为92％，乳化时间为65秒，pH为6.35，粒径为20 nm，ζ电势为-12,40且对三者稳定个月。结论：SNEDDS可以提高山竹果皮作为水溶性较差的模型药物的扩散速度。根据活性化合物在油，表面活性剂和助表面活性剂中的溶解度，筛选了各种山竹果皮样品作为SNEDDS的候选对象。单纯形晶格设计方法可用于在SNEDDS上获得最佳配方。

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