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首页> 外文期刊>Journal of Young Pharmacists >Nephroprotective Effect of Pterocarpus indicus Willd. Leaves: Observation From Plasma Urea and Creatinine Levels Against Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats
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Nephroprotective Effect of Pterocarpus indicus Willd. Leaves: Observation From Plasma Urea and Creatinine Levels Against Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats

机译：紫罗兰（Pterocarpus indicus Willd）的肾脏保护作用。叶：从血浆尿素和肌酐水平观察庆大霉素诱导的Sprague-Dawley大鼠肾毒性

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Introduction: Pterocarpus indicus Willd. has been widely used empirically for treating canker sore, antibacterial and kidney disease. Objective: This study aimed to evaluate nephroprotective effect water-boiled P. indicus leaves against gentamicin-induced nephrotoxicity in rats observed from plasma urea and creatinine levels. Materials and Methods: In this study, thirty (30) male rats divided into five treatment groups. The treatment groups consisted of the normal group, induction group received gentamicin (80 mg/kg body weight per day i.p.) and a group which received water-boiled P. indicus leaves with a dose of 28.8 mg/kg, 57.6 mg/kg, and 115.2 mg/kg body weight per day p.o. All groups received treatment for 21 days. At the 15th day, the animals received gentamicin i.p. for 7 days. At the 22nd day, the blood was collected from orbital sinus. The plasma urea and creatinine levels were measured by Berthelot method for plasma urea and colorimetric method for plasma creatinine. Results: The highest dose of 115.2 mg/kg water-boiled P. indicus was decreased plasma urea and creatinine levels also significantly different (p<0,05) compared induction group. Conclusions: Water-boiled P. indicus leaves have a potential to prevent gentamicin-induced nephrotoxicity might be due to its antioxidant and free radical scavenging activity.
机译：简介：印度紫檀。在经验上已广泛用于治疗溃疡疮，抗菌和肾脏疾病。目的：本研究旨在通过血浆尿素和肌酐水平评估水煮印度梧桐叶对庆大霉素诱导的大鼠肾毒性的保护作用。材料和方法：在本研究中，将三十（30）只雄性大鼠分为五个治疗组。治疗组包括正常组，诱导组接受庆大霉素（ip每天80 mg / kg体重）和接受水煮印度梧桐叶的组，剂量分别为28.8 mg / kg，57.6 mg / kg，和每天口服115.2 mg / kg体重所有组接受治疗21天。在第15天，动物接受庆大霉素腹膜内注射。 7天。在第22天，从眼眶窦收集血液。血浆尿素和肌酐水平通过Berthelot法测定血浆尿素，比色法测定血浆肌酐。结果：最高剂量115.2 mg / kg的水煮印度梧桐降低了血浆尿素，肌酐水平也与诱导组相比有显着差异（p <0.05）。结论：水煮印度梧桐叶具有预防庆大霉素诱导的肾毒性的潜力，这可能是由于其抗氧化剂和清除自由基的活性。

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