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首页> 外文期刊>Journal of Translational Medicine >Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients
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Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients

机译：早期缺血性脑卒中患者循环中的CD133 + CD34 +祖细胞与可溶性ICAM-1呈负相关

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Background and Purpose Both endothelial progenitor cells (EPC) and markers of neuroinflammation are candidate biomarkers for stroke severity and outcome prediction. A relationship between EPC and neuroinflammatory markers in early stroke is not fully elucidated. The objectives were to investigate correlations between EPC and neuroinflammation markers (adhesion molecules ICAM-1, VCAM-1, E-selectin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, endothelin (ET)-1, markers of tissue injury (matrix metalloproteinases (MMP)-9 and tissue inhibitor of matrix metalloproteinases (TIMP)-1) in early stroke patients. Methods We prospectively recruited symptomatic patients with ischemic cerebrovascular disease. We assessed stroke severity by using of acute (diffusion-weighted imaging (DWI) and final lesion volumes (fluid attenuated inversion recovery (FLAIR). We measured serum soluble ICAM-1, VCAM-1, E-selectin, MMP-9, TIMP-1 and plasma TNF-α, IL-6, ET-1 by ELISA, and quantified EPC in mononuclear fraction of peripheral blood on days 1 and 3 in 17 patients (mean(SD) age 62(14), with admission National Institutes of Health Stroke Scale (NIHSS) 10(8)) selected from 175 patients with imaging confirmed ischemic stroke. Non-parametric statistics, univariate and multivariate analysis were used. Results Only ICAM-1 inversely correlated with EPC subset CD133+CD34+ on day 1 (Spearman r = -0.6, p Conclusion Our study showed that high ICAM-1 is associated with low CD133+CD34+subset of EPC. Biomarkers of neuroinflammation may predict tissue injury and stroke severity in early ischemia.
机译：背景与目的内皮祖细胞（EPC）和神经炎症标记物都是卒中严重程度和结果预测的候选生物标记物。早期卒中中EPC与神经炎症标志物之间的关系尚未完全阐明。目的是研究EPC和神经炎症标记物（粘附分子ICAM-1，VCAM-1，E-选择素，肿瘤坏死因子（TNF）-α，白介素（IL）-6，内皮素（ET）-1，标记物之间的相关性方法：我们前瞻性招募了有症状的缺血性脑血管病患者，并采用急性（扩散-脑卒中）评估了卒中的严重程度，以评估卒中患者的组织损伤（基质金属蛋白酶（MMP）-9和基质金属蛋白酶（TIMP）-1组织抑制剂）的水平。加权成像（DWI）和最终病变体积（流体衰减反转恢复（FLAIR）。我们测量了血清可溶性ICAM-1，VCAM-1，E-选择素，MMP-9，TIMP-1和血浆TNF-α，IL-6 ，通过ELISA测得的ET-1以及量化的EPC在17例患者中的第1天和第3天的外周血单核部分（平均年龄为62（14）岁，入院时为美国国立卫生研究院卒中量表（NIHSS）10（8） ）选自175例影像学确诊的缺血性卒中患者。非参数统计，单变量和多元分析。结果第一天，只有ICAM-1与EPC亚群CD133 + CD34 +呈负相关（Spearman r = -0.6，p）结论我们的研究表明，高ICAM-1与EPC的CD133 + CD34 +亚群相关。缺血早期的组织损伤和中风严重性。

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