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首页> 外文期刊>Journal of Young Pharmacists >Colon Specific Drug Delivery: Effect of Eudragit Enteric Coating on Hydroxypropyl Methylcellulose Matrix Tablets of Flurbiprofen
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Colon Specific Drug Delivery: Effect of Eudragit Enteric Coating on Hydroxypropyl Methylcellulose Matrix Tablets of Flurbiprofen

机译：结肠特异性药物递送：Eudragit肠溶衣对氟比洛芬羟丙基甲基纤维素基质片剂的影响

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Aims: The present research is focused on developing flurbiprofen colon-specific tablets based on timed release and pHsensitivity. Methods and Material: This study is designed to study the effect of eudragit coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the colon-specific release. Hydroxypropyl methylcellulose matrix tablets were prepared by wet granulation method and coated with eudragit S100 using dip coating method. Then the tablets were evaluated for different physical parameters, compatibility studies, in vitro dissolution and in vivo x-ray imaging studies. Statistical Analysis: In the stability studies, paired t-test is employed to determine the significance of difference at 0.05 level. Results: Flurbiprofen colon-specific tablets have been characterized for weight variation, hardness, friability and drug content. Based on in vitro drug release, the formulation F6 showed the low amount of drug release (18.41 ± 0.68%) in the initial lag period followed 100.43 ± 3.33% in 24 h. Compatibility studies revealed that there was no interaction between drug and the polymers. Similarity index value was found as 95.01, which is more than 50 indicates similarity between the dissolution profile before and after storage. In support of the dissolution studies, x-ray imaging studies revealed that tablets reached the colon without disintegrating in the upper gastro intestinal tract. Conclusion: From the above results, it is obvious that the developed flurbiprofen enteric coated matrix tablets are suitable for colonic delivery.
机译：目的：本研究专注于基于定时释放和pH敏感性开发氟比洛芬结肠特异性片剂。方法和材料：本研究旨在研究eudragit包衣对羟丙基甲基纤维素基质中药物释放以实现结肠特异性释放的影响。通过湿法制粒制备羟丙基甲基纤维素基质片剂，并使用浸涂法用eudragit S100进行包衣。然后评估片剂的不同物理参数，相容性研究，体外溶出度和体内X射线成像研究。统计分析：在稳定性研究中，采用配对t检验确定0.05水平差异的显着性。结果：氟比洛芬结肠特异性片剂的特征在于重量变化，硬度，易碎性和药物含量。根据体外药物释放，制剂F6在最初的滞后期显示出较低的药物释放量（18.41±0.68％），然后在24小时内为100.43±3.33％。兼容性研究表明，药物与聚合物之间没有相互作用。发现相似性指数值为95.01，大于50表示储存前后溶出曲线之间的相似性。为了支持溶出度研究，X射线成像研究显示片剂到达结肠而没有在上消化道中崩解。结论：从以上结果可以明显看出，所开发的氟比洛芬肠溶衣基质片剂适合于结肠递送。

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