Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity

Roger Colobran; Maria del Pilar Armengol; Eduard Porta; Paula A Correa; Ricardo Pujol-Borrell

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Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity

机译：唐氏综合症患者胸腺中的AIRE降低和混杂基因表达可能解释了自身免疫易感性

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来源
《Journal of Translational Medicine》 |2012年第3期|共页
作者
Roger Colobran; Maria del Pilar Armengol; Eduard Porta; Paula A Correa; Ricardo Pujol-Borrell;
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中图分类心脏、血管（循环系）疾病;
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1. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus [J] . Matthieu Giraud, Richard Taubert, Claire Vandiedonck, Nature . 2007,第7156期

机译：一个IRF8结合启动子变体和AIRE控制CHRNA1在胸腺中的混杂表达。
2. "Promiscuous" expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity? [J] . Klein L, Kyewski B Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." . 2000,第9期

机译：胸腺组织抗原的“混杂”表达：T细胞耐受性和自身免疫的关键吗？
3. Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes. [J] . Li Y, Liu Y, Strickland FM, Experimental Gerontology . 2010,第4期

机译：DNA甲基转移酶水平的年龄依赖性下降和低甲基化微量营养素水平的协同作用促进了与自身免疫和急性冠脉综合征有关的基因的过表达。
4. Expression of genes involved in stress, toxicity, inflammation, and autoimmunity, and levels of heavy metals in human blood [C] . R. Monastero, C. Vacchi-Suzzi, C. Marsit, Annual conference of the International Society of Exposure Science . 2017

机译：涉及压力，毒性，炎症和自身免疫的基因表达以及人血中的重金属含量
5. Aire and human insulin expression in the thymus of a transgenic mouse towards the development of a humanized Type 1 Diabetes model [D] . Ladva, Chandresh Nanji 2010

机译：Aire和人胰岛素在转基因小鼠的胸腺中向人源化1型糖尿病模型发展的表达
6. Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity [O] . Roger Colobran, Maria del Pilar Armengol, Eduard Porta, 2012

机译：唐氏综合症个体胸腺中的AIRE降低和混杂基因表达可能解释了自身免疫易感性
7. Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity [O] . Roger Colobran, Maria del Pilar Armengol, Eduard Porta, 2013

机译：唐氏综合症个体胸腺中的AIRE降低和混杂基因表达可能解释了自身免疫易感性

Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity

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