...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Translational Medicine >Calcium Sulfate and Platelet-Rich Plasma make a novel osteoinductive biomaterial for bone regeneration
【24h】

Calcium Sulfate and Platelet-Rich Plasma make a novel osteoinductive biomaterial for bone regeneration

机译：硫酸钙和富含血小板的血浆制成了一种新型的骨诱导生物骨再生生物材料

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of biological processes that culminate in bone regeneration. Thus, we engineered CS-Platelet, a biomaterial based on the combination of Calcium Sulfate and Platelet-Rich Plasma in which Calcium Sulfate also acts as an activator of the platelets, therefore avoiding the need to activate the platelets with an agonist. Methods First, we tested CS-Platelet in heterotopic (muscle) and orthotopic (bone) bone regeneration bioassays. We then utilized CS-Platelet in a variety of dental and craniofacial clinical cases, where regeneration of bone was needed. Results The heterotopic bioassay showed formation of bone within the muscular tissue at the site of the implantation of CS-Platelet. Results of a quantitative orthotopic bioassay based on the rat calvaria critical size defect showed that only CS-Platelet and recombinant human BMP2 were able to induce a significant regeneration of bone. A non-human primate orthotopic bioassay also showed that CS-Platelet is completely resorbable. In all human clinical cases where CS-Platelet was used, a complete bone repair was achieved. Conclusion This study showed that CS-Platelet is a novel biomaterial able to induce formation of bone in heterotopic and orthotopic sites, in orthotopic critical size bone defects, and in various clinical situations. The discovery of CS-Platelet may represent a cost-effective breakthrough in bone regenerative therapy and an alternative or an adjuvant to the current treatments.
机译：背景技术在本研究中，我们介绍了一种能够诱导骨骼再生的新型简单生物材料。我们推论，用钙和大量活化的血小板滋养骨骼缺损可能会引发一系列生物学过程，最终导致骨骼再生。因此，我们设计了CS-Platelet，这是一种基于硫酸钙和富含血小板血浆的组合的生物材料，其中硫酸钙还充当了血小板的活化剂，因此避免了使用激动剂活化血小板的需要。方法首先，我们在异位（肌肉）和原位（骨）骨再生生物测定法中测试了CS-血小板。然后，我们在需要骨再生的各种牙科和颅面临床案例中使用了CS-Platelet。结果异位生物测定显示在CS-Platelet植入部位的肌肉组织内有骨形成。基于大鼠颅骨临界大小缺损的定量原位生物测定结果表明，仅CS-血小板和重组人BMP2能够诱导骨骼的显着再生。非人类的灵长类动物原位生物测定法也表明CS血小板是完全可吸收的。在所有使用CS-Platelet的人类临床病例中，都可以实现完全的骨修复。结论该研究表明CS-血小板是一种新型生物材料，能够诱导异位和原位，原位临界大小的骨缺损以及各种临床情况下的骨形成。 CS-Platelet的发现可能代表了骨再生治疗的一项具有成本效益的突破，并且是当前治疗的替代方案或佐剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号