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首页> 外文期刊>Journal of Translational Medicine >The development of a Biobank of cancer tissue samples from World Trade Center responders
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The development of a Biobank of cancer tissue samples from World Trade Center responders

机译：世界贸易中心响应者开发的癌症组织样本生物库的开发

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World Trade Center?(WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the general population. There is a need to supplement current epidemiologic cancer follow-up with a cancer tissue bank in order to better elucidate a possible connection between each cancer and past WTC exposure. This work describes the implementation of a tissue bank system for the WTC newly diagnosed cancers, focused on advancing the understanding of the biology of these tumors. This will ultimately impact the modalities of treatment, and the probability of success and survival of these patients. WTC Responders who participated (as employees or volunteers) in the rescue, recovery and cleanup efforts at the WTC sites have been enrolled at Mount Sinai in the World Trade Center Health Program. Responders with cancer identified and validated through linkages with New York, New Jersey, Pennsylvania, and Connecticut cancer registries were eligible to participate in this biobank. Potential participants were contacted through letters, phone calls, and emails to explain the research study, consent process, and to obtain the location where their cancer procedure was performed. Pathology departments were contacted to identify and request tissue samples. All the 866 solid cancer cases confirmed by the Data Center at Mount Sinai have been contacted and consent was requested for retrieval and storage of the tissue samples from their cancer. Hospitals and doctors’ offices were then contacted to locate and identify the correct tissue block for each patient. The majority of these cases consist of archival paraffin blocks from surgical patients treated from 2002 to 2015. At the time of manuscript writing, this resulted in 280 cancer samples stored in the biobank. A biobank of cancer tissue from WTC responders has been compiled with 280 specimens in storage to date. This tissue bank represents an important resource for the scientific community allowing for high impact studies on environmental exposures and cancer etiology, cancer outcome, and gene-environment interaction in the unique population of WTC responders.
机译：世界贸易中心（WTC）的响应者暴露于粉尘，烟雾，化学物质和致癌物的混合物中。与普通人群相比，该人群中癌症发生率的研究报告了患癌风险升高。需要用癌症组织库来补充当前的流行病学癌症随访，以便更好地阐明每种癌症与过去的WTC暴露之间的可能联系。这项工作描述了针对WTC新诊断的癌症的组织库系统的实施，重点是增进对这些肿瘤生物学的理解。这最终将影响治疗方式以及这些患者成功和存活的可能性。参加（作为员工或志愿者）在WTC站点进行救援，恢复和清理工作的WTC响应者已被加入世贸中心卫生计划的西奈山。通过与纽约，新泽西，宾夕法尼亚州和康涅狄格州癌症登记处的联系确定并验证的癌症应答者有资格参加该生物库。通过信件，电话和电子邮件与潜在的参与者进行了联系，以解释研究，同意过程，并获得进行癌症手术的地点。与病理部门联系以识别和索取组织样本。已联系西奈山数据中心确认的所有866例实体癌病例，并已征得同意以从其癌症中取出和保存组织样本。然后与医院和医生办公室联系，以找到并确定每位患者的正确组织块。这些病例中的大多数由2002年至2015年治疗的外科手术患者的石蜡块组成。在撰写手稿时，这有280个癌症样品存储在生物库中。迄今为止，已经收集了来自WTC响应者的癌症组织生物库，其中包含280个标本。该组织库代表了科学界的重要资源，可以在独特的WTC响应者群体中对环境暴露和癌症病因，癌症结果以及基因与环境的相互作用进行高影响力的研究。

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