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首页> 外文期刊>Jundishapur Journal of Microbiology >Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals
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Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals

机译：从癌症患者和正常人口腔中分离出不同念珠菌的毒力因子的比较

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Candida yeast is a normal flora of the mucous membrane of the oral cavity. Various enzymes secreted by Candida species play the role of virulence factors in different Candida infections including in cancer patients.This study aimed at comparing phospholipase, proteinase, esterase, and hemolytic activities in different Candida species isolated from the oral cavity of cancer patients and normal people.This study was conducted on 36 cancer patients and 36 healthy people. MspI restriction enzyme for PCR-RFLP method was used to identify the Candida species. The enzymatic activity index (EAI) was measured for each enzyme using the relevant protocols.Candida albicans was the most frequent species with the frequency of 26 (72%) and 31 (81.1%) in cancer patients and healthy people, respectively. In healthy individuals and patients, the mean phospholipase activity of Candida isolates was 0.795 and 0.775, proteinase activity was 0.7531 and 0.7558, esterase activity was 0.6142 and 0.7186, and hemolysin activity was 0.6317 and 0.5756, respectively.The results showed that C. albicans was the most frequent Candida species isolated from healthy people and patients. Phospholipase, proteinase, and hemolysin activity of Candida species was higher in patients than in healthy people and hemolytic activity was significantly higher in patients than in healthy subjects (P & 0.05). However, Candida species in both groups were positive for esterase activity but the mean activity of this enzyme was significantly higher in the healthy group than in the patient group.
机译：念珠菌酵母是口腔粘膜的正常菌群。念珠菌物种分泌的各种酶在包括癌症患者在内的不同念珠菌感染中均发挥毒力因子的作用。本研究旨在比较从癌症患者和正常人口腔中分离的不同念珠菌物种的磷脂酶，蛋白酶，酯酶和溶血活性。该研究针对36位癌症患者和36位健康人群进行。用PCR-RFLP法的MspI限制酶鉴定假丝酵母菌。使用相关方案测量每种酶的酶活性指数（EAI）。白色念珠菌是癌症患者和健康人中最常见的物种，频率分别为26（72％）和31（81.1％）。在健康个体和患者中，念珠菌分离物的平均磷脂酶活性分别为0.795和0.775，蛋白酶活性分别为0.7531和0.7558，酯酶活性分别为0.6317和0.7186，溶血素活性分别为0.6317和0.5756。从健康人群和患者中分离出的最常见念珠菌。患者中念珠菌种类的磷脂酶，蛋白酶和溶血素活性高于健康人，并且患者的溶血活性显着高于健康人（P ＜0.05）。然而，两组中的念珠菌属酯酶活性均为阳性，但健康组中该酶的平均活性显着高于患者组。

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